CYB5R3
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Official Full Name
cytochrome b5 reductase 3 -
Overview
This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the;endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form;exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of;fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble;fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both;membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing;results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. -
Synonyms
CYB5R3;cytochrome b5 reductase 3;DIA1, diaphorase (NADH) (cytochrome b 5 reductase);NADH-cytochrome b5 reductase 3;B5R;Cytochrome b5 reductase;DIA1;Diaphorase 1;Diaphorase-1;NADH cytochrome b5 reductase 3;NADH-cytochrome b5 reductase 3 membrane-bound form;NADH-cytochrome b5 reductase 3 soluble form;NB5R3_HUMAN;OTTHUMP00000028761;OTTHUMP00000198435;OTTHUMP00000198574;OTTHUMP00000198662;OTTHUMP00000198665
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Rat
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CYB5R3 involved in several pathways and played different roles in them. We selected most pathways CYB5R3 participated on our site, such as Amino sugar and nucleotide sugar metabolism,Metabolism,Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYB5R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | FAM36A,MED20,NAALAD2,DBH,CYGB2,PITPNB,CYP2AD2,CYP24A1,GSTO2,C20orf7 |
| Amino sugar and nucleotide sugar metabolism | HK3,GMPPA,UGDH,nanA,UGP2,GMPPAA,CMASA,GPIB,HEXB,CYB5RL |
| Metabolism of vitamins and cofactors | SLC25A32,PDZD11,SLC5A6A,ELA2,SLC25A32A,LOC100686744,ELA2L,TCN1,SLC25A16,SLC52A3 |
| Metabolism of water-soluble vitamins and cofactors | ELA2L,SLC46A1,PDZD11,CYB5A,NAMPT,GSTO2,SLC25A32B,SLC2A3,SLC5A6B,SLC25A32 |
| cytochrome P450 | CYB5A,CYP4V2,CYP2A7,CYP4F12,POR,CYP2W1,CYP4Z1,CYP20A1,CYB5B |
| Vitamin C (ascorbate) metabolism | CYB5A,SLC23A2 |
Protein Function
CYB5R3 has several biochemical functions, for example, ADP binding,AMP binding,FAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYB5R3 itself. We selected most functions CYB5R3 had, and list some proteins which have the same functions with CYB5R3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| flavin adenine dinucleotide binding | NOS3,DUS1L,GULO,DUS3L,NDOR1,AOX1,ACADS,DHCR24,FMO5,FMO1 |
| ADP binding | MYH10,MYO18A,P2RY1,MIEF1,ATP1A1,ADCK3,MYO3A,PRPS1,HSP104,CHORDC1 |
| NAD binding | GPD1L,IDH3G,AOX3,HSD3B5,MDH1,LDHA,HADHA,GRHPRB,IDH3B,GPD1B |
| cytochrome-b5 reductase activity, acting on NAD(P)H | CYB5R1,CYB5R4,CYB5R2,NQO1,CYB5RL,POR |
| FAD binding | MTRR,DAO.3,DAO.1,PRODH,MICAL2B,ACOX1,CRY2,DERL3,KMO,MICAL2 |
| AMP binding | PRKAG2,PRKAG1,FBP1,PYGM,PRPS1,ACSS2,PRPS2,PYGL,ACSS1,APRT |
Interacting Protein
CYB5R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYB5R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYB5R3.
fad;PRKAB1;1C;P
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