CTPS2

  • Official Full Name

    CTP synthase II

  • Overview

    The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

  • Synonyms

    CTPS2;CTP synthase II;CTP synthase 2;CTP synthetase 2;CYTIDINE 5 PRIME TRIPHOSPHATE SYNTHETASE 2;FLJ43358;MGC32997;PYRG2_HUMAN;UTP--ammonia ligase 2;UTP-ammonia ligase;CTP synthetase type 2;CTP synthetase isoform;cytidine 5-triphosphate synthetase 2

Recombinant Proteins

  • Rat
  • Human
  • Chicken
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • Flag

    Involved Pathway

    CTPS2 involved in several pathways and played different roles in them. We selected most pathways CTPS2 participated on our site, such as Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pyrimidine metabolism UCKL1,NT5C2,CTPS1A,CMPK1,CDA,POLR2B,POLD1,DCTPP1,NME4,NME3
    Metabolic pathways SGMS2,PYGMA,LSS,ATP6V0A4,B4GALT7,EHHADH,ATP6V0C,LDHBB,AKR1B8,PEMT

    Protein Function

    CTPS2 has several biochemical functions, for example, ATP binding,CTP synthase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTPS2 itself. We selected most functions CTPS2 had, and list some proteins which have the same functions with CTPS2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding JUP,RTN4RL2A,HDLBP,CSNK1G2,ZNF274,NOTCH4,ETV1,Fert2,SMAD4,COG4
    CTP synthase activity CTPS1A
    ATP binding PSTK,AURKC,POMK,ATP13A5,NLRC4,CSNK2A2,KIF20A,GRK7B,PAPOLA,HSP90AB1

    Interacting Protein

    CTPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTPS2.

    SPG21;OTUD5;FGFR1;CTBP2;RPL37A;RPL23A;15-deoxy-delta(12,14;SNX3;NASP

    Resources

    References

    • Dymond, MK; Hague, CV; et al. An in vivo ratio control mechanism for phospholipid homeostasis: evidence from lipidomic studies. JOURNAL OF THE ROYAL SOCIETY INTERFACE 10:-(2013).
    • Lee, JW; Kim, SW; et al. Functional Characterization of the alpha- and beta-Subunits of a Group II Chaperonin from Aeropyrum pernix K1. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 23:818-825(2013).

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