CTCF

  • Official Full Name

    CCCTC-binding factor (zinc finger protein)

  • Overview

    This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

  • Synonyms

    CTCF;CCCTC-binding factor (zinc finger protein);MRD21;transcriptional repressor CTCF;CTCFL paralog;11-zinc finger protein;11 zinc finger transcriptional repressor

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • Non
  • His
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CTCF-15H Recombinant Human CTCF protein E.coli Human Non
CTCF-1651R Recombinant Rat CTCF Protein Mammalian Cells Rat His
CTCF-16H Recombinant Human CTCF protein, GST-tagged Wheat Germ Human GST 1-727 a.a.
CTCF-253Z Recombinant Zebrafish CTCF Mammalian Cells Zebrafish His
CTCF-26436TH Recombinant Human CTCF Wheat Germ Human Non 100 amino acids
CTCF-4013M Recombinant Mouse CTCF Protein Mammalian Cells Mouse His
CTCF-6884C Recombinant Chicken CTCF Mammalian Cells Chicken His
CTCF-7213HCL Recombinant Human CTCF 293 Cell Lysate HEK293 Human Non
CTCF-1310R Recombinant Rat CTCF Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CTCF-1310R-B Recombinant Rat CTCF Protein Pre-coupled Magnetic Beads HEK293 Rat
CTCF-1699H Recombinant Human CTCF Protein (Met1-Ile154), N-His tagged E.coli Human His Met1-Ile154
CTCF-1700H Recombinant Human CTCF Protein (Met1-Ile154) E.coli Human Non Met1-Ile154
CTCF-2043M Recombinant Mouse CTCF Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CTCF-2043M-B Recombinant Mouse CTCF Protein Pre-coupled Magnetic Beads HEK293 Mouse
CTCF-2364H Recombinant Human CTCF protein, His-tagged E.coli Human His 266-727aa
CTCF-730HF Recombinant Full Length Human CTCF Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 727 amino acids

    Involved Pathway

    CTCF involved in several pathways and played different roles in them. We selected most pathways CTCF participated on our site, such as SIDS Susceptibility Pathways,TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTCF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    SIDS Susceptibility Pathways MAZ,ASCL1,YBX1,CDCA7L,PKNOX1,ECE1,POU2F2,TSPYL1,TAC1,MECP2
    TGF-beta Receptor Signaling Pathway VDRB,STK11IP,TGFBR3,EID2,RUNX2A,ZEB2A,TRAP1,ENG,NFYBB,STAMBPL1

    Protein Function

    CTCF has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin insulator sequence binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTCF itself. We selected most functions CTCF had, and list some proteins which have the same functions with CTCF. You can find most of the proteins on our site.

    Function Related Protein
    sequence-specific DNA binding THRAA,RAD21A,HOXB1,IRX3A,TSN,FOXJ1B,HOXA3,MYOG,OTP,CREMB
    protein binding CTIF,CEACAM21,LPL,BMPR1B,TPM3,PLEKHM1,GABRG2,WFDC9,PITPNM1,CLIC2
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding PYDC3,NKX6-2,TGIF1,BCL11AB,KCNIP3,GATA1,SP3,TCF3,NFIL3-6,ASCL2
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding BARHL1A,EP300,MAF,MSGN1,IKZF3,CREB3L3,OSR2,DLX2,PLAGL1,RAD21
    transcription corepressor activity ALX1,MXI1,NFIL3,ZFPM1,JUNB,HDAC9,PFDN5,YWHAB,AES,SKOR1A
    transcription regulatory region DNA binding NFE2L2,TA,LEF1,OVOL2,IKZF2,KLF1,YY1,POU5F1,GFI1,SALL3B
    transcription factor activity, sequence-specific DNA binding MZF1,ATF1,VDRB,TADA3,NFIL3,TFEB,ZNF445,TSC22D3,DBPB,HOXC6B
    zinc ion binding CPZ,RNF41,PPARDB,PAPLNB,PGLYRP3,RNF2,ZCCHC16,LIMK2,CBL,PDLIM5
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NR2C1,HOXA2,E2F8,PHOX2B,RFX1A,CEBPA,KCNIP3,CREB1,SP1,NFATC4

    Interacting Protein

    CTCF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTCF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTCF.

    HDLBP;ZMYM4;KDM5B;mdm2_human_probe;CHD8

    Resources

    References

    • Lin, SG; Guo, CG; et al. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:1815-1820(2015).
    • Batlle-Lopez, A; Cortiguera, MG; et al. Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus. ONCOGENE 34:246-256(2015).

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