CSTF2
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Official Full Name
cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa -
Overview
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3 end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3-untranslated region of mRNAs. -
Synonyms
CSTF2;cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa;cleavage stimulation factor, 3 pre RNA, subunit 2, 64kD;cleavage stimulation factor subunit 2;CF-1 64 kDa subunit;CSTF 64 kDa subunit;betaCstF-64 variant 2;cleavage stimulation factor 6
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian Cells
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CSTF2 involved in several pathways and played different roles in them. We selected most pathways CSTF2 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSTF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | MED20,POU2F1B,ZNF227,SRSF11,AIMP1,NR4A2A,TET3,CDK9,ZNF461,PUS1 |
| mRNA 3-end processing | CSTF3,NUDT21,CLP1,SRSF11,SFRS3A |
| RNA Polymerase II Transcription | GM3258,CSTF1,PAPOLA,CCNT2A,U2AF2,RNPS1,SRSF11,SSRP1A,SLBP,NUDT21 |
| Processing of Capped Intronless Pre-mRNA | ZFP473,LSM10,NUDT21,SLBP,LSM11,CSTF1,ZNF473,CLP1,CSTF3,PAPOLA |
| Processing of Intronless Pre-mRNAs | NUDT21,CSTF1,CSTF3,PAPOLA,CLP1 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPA0A,HNRPL,SF3A1,BCAS2,CD2BP2,SF3B4,PTBP1B,SLBP,HNRNPH1,HNRNPF |
| RNA Polymerase II Transcription Termination | NUDT21,LSM11,CLP1,CSTF1,SRSF11,ZFP473,PAPOLA,THOC4,U2AF2,SLBP |
| Cleavage of Growing Transcript in the Termination Region | NUDT21,CSTF1,LSM11,ZFP473,PAPOLA,CSTF3,LSM10,RNPS1,U2AF2,ZNF473 |
Protein Function
CSTF2 has several biochemical functions, for example, RNA binding,mRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSTF2 itself. We selected most functions CSTF2 had, and list some proteins which have the same functions with CSTF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | RAB25A,DCLK2,PDPK1B,ABCB6A,Aatk,HNRNPDL,NT5C3A,UBE2D1A,MSI2B,NLRP9B |
| protein binding | PCBD2,CBFB,CYFIP1,BIRC7,KRTAP19-7,RPLP2,SOX10,RTP3,JMY,ANKHD1 |
| poly(A) RNA binding | GRWD1,ITM2B,MRPL40,AHNAK,UBE2I,CCT3,YTHDC2,IFIT5,EIF3A,NAT10 |
| mRNA binding | DPPA5A,RPS26,PARK7,ZFP36,CSTF3,SNRNP70,NXF2,FXR2,NOVA1,KIAA0020 |
| RNA binding | FAM103A1,SRSF10,EIF4H,ZFP36L3,HNRPL,RPL3,ATXN1A,DDX59,KHDRBS1,CDKN2AIP |
Interacting Protein
CSTF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSTF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSTF2.
BARD1;UBQLN1;HGS;SS18L1;TFG
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