CSNK2A1
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Official Full Name
casein kinase 2, alpha 1 polypeptide -
Overview
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. -
Synonyms
CSNK2A1;casein kinase 2, alpha 1 polypeptide;casein kinase II subunit alpha;CK II alpha;protein kinase CK2;CK2 catalytic subunit alpha;casein kinase II alpha 1 subunit;CKII;CK2A1
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Mouse
- Zebrafish
- Insect Cell
- Mammalian Cell
- E.coli
- Insect Cells
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- In Vitro Cell Free System
- Insect (sf21)
- HEK293T
- E. coli
- GST
- His
- Flag
- Non
- His&GST
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
CSNK2A1 involved in several pathways and played different roles in them. We selected most pathways CSNK2A1 participated on our site, such as Adherens junction,Alpha-synuclein signaling,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSNK2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | NCAPD3,LIN37,MASTL,CENPK,CTDNEP1A,KNTC1,NCAPG,NIPBLB,DNA2,APITD1 |
| Adherens junction | BAIAP2A,ACTN3,VCL,SMAD3,ACTN2,CREBBP,CSNK2A2A,SNAI2,EP300,CSNK2A2 |
| Cell cycle | CENPA,RBBP4,E2F4,STAG1,HTATIP,ORC4L,CDC14B,SMC3,RAD21B,BORA |
| Condensation of Prometaphase Chromosomes | CSNK2B,NCAPG,NCAPH,SMC2,SMC4,CSNK2A2,NCAPD2 |
| BDNF signaling pathway | EIF4EBP1,SIRPA,IGF2BP1,FRS3,DOK5,CDK5,CDH2,KCNN2,EGR1,BCL2L11 |
| BCR signaling pathway | POU2F2,IBTK,PAG1,DOK1,CSK,NETO2,MALT1,MAP4K1 |
| Alpha-synuclein signaling | TOR1A,BLK,STUB1,PARK7,KLK6,FKBP1A |
| Axon guidance | ITGB3A,EPHA1,DPYSL5B,ABLIM2,ARPC1B,ARHGEF12,RHOAE,PLXNB2,ROBO3,NFATC2 |
Protein Function
CSNK2A1 has several biochemical functions, for example, ATP binding,Hsp90 protein binding,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSNK2A1 itself. We selected most functions CSNK2A1 had, and list some proteins which have the same functions with CSNK2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | BMP2K,MAP2K2,STK35L,MAPK12A,MAPK12,IKBKB,CSNK1G2A,ACVRL1,PDPK1,SGK2A |
| Hsp90 protein binding | HDAC6,PACRG,ERBB2,UNC45B,PPEF2,USP19,HIF1A,CHORDC1,GBP1,EIF2AK3 |
| protein binding | LXN,CNIH2,CCDC70,TOMM34,NOS1,C16orf87,C9orf9,PHOSPHO2,RPS20,GSN |
| ATP binding | UBE2E2,BCR,ASNS,DDX3X,EPHA7,RAD54L,MAP3K1,VARS2,ULK4,THG1L |
| protein N-terminus binding | STX5,SUV39H1,RBPJ,ERCC6,PDLIM5,TAF11,ERCC4,SNCA,TBL1XR1,HAX1 |
Interacting Protein
CSNK2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSNK2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSNK2A1.
CSNK2B;PTPN1;CSNK2A2
CSNK2A1 Related Signal Pathway
Resources
Research Area
Histone PhosphorylationIntracellular Kinases in the Akt Pathway
Casein Kinases
Wnt Intracellular Signaling
Related Services
Related Products
References
