CRYBB1
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Official Full Name
crystallin, beta B1 -
Overview
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3. -
Synonyms
CRYBB1;crystallin, beta B1;beta-crystallin B1;Beta crystallin B1;CRYBB 1;Crystallin beta B1;Eye lens structural protein;OTTHUMP00000028719;OTTHUMP00000198858;beta-B1 crystallin;CATCN3
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- His&GST
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CRYBB1 involved in several pathways and played different roles in them. We selected most pathways CRYBB1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYBB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRYBB1 has several biochemical functions, for example, protein binding,structural constituent of eye lens. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYBB1 itself. We selected most functions CRYBB1 had, and list some proteins which have the same functions with CRYBB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MS4A12,SCRN1,DNAJA1,PEF1,RPS25,DNMT3L,APOD,KLK8,SSB,RABGAP1 |
| structural constituent of eye lens | CRYGN2,CRYBA4,LIM2,LIM2.1,CRYBA2,ATXN1,BFSP2,CRYGS,LIM2.3,LIM2.5 |
Interacting Protein
CRYBB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYBB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYBB1.
CRYBA1;TERF1;CRYBA1;CRYBA1;CRYBA2;CRYBA4;TERF2IP
Resources
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References
- Terrell, AM; Anand, D; et al. Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes. EXPERIMENTAL EYE RESEARCH 131:42-55(2015).
- Benzekri, H; Armesto, P; et al. De novo assembly, characterization and functional annotation of Senegalese sole (Solea senegalensis) and common sole (Solea solea) transcriptomes: integration in a database and design of a microarray. BMC GENOMICS 15:-(2014).
