CRISP1
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Official Full Name
cysteine-rich secretory protein 1 -
Overview
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CRISP1;cysteine-rich secretory protein 1;acidic epididymal glycoprotein like 1 , AEGL1;ARP;CRISP 1;HSCRISP1D;HSCRISP1G;HUMARP;Acidic epididymal glycoprotein homolog;Acidic epididymal glycoprotein like 1;AEG like protein;AEG related protein;AEGL1;Cysteine rich secretory protein 1;Cysteine rich secretory protein 1 delta;Protein DE like;AEG-like protein;AEG-related protein;acidic epididymal glycoprotein-like 1;cysteine-rich secretory protein-1 delta;CRISP-1
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Fc
Involved Pathway
CRISP1 involved in several pathways and played different roles in them. We selected most pathways CRISP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRISP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRISP1 has several biochemical functions, for example, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRISP1 itself. We selected most functions CRISP1 had, and list some proteins which have the same functions with CRISP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel regulator activity | NRXN1,NRXN3,CAV3,STIM1,STIM1A,CACNA2D2,SGK1,GRM3,CACNA2D3,CACNA2D4 |
Interacting Protein
CRISP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRISP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRISP1.
Resources
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References
- Maldera, JA; Munoz, MW; et al. Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3. MOLECULAR HUMAN REPRODUCTION 20:341-349(2014).
- Munoz, MW; Ernesto, JI; et al. Evaluation of Testicular Sperm CRISP2 as a Potential Target for Contraception. JOURNAL OF ANDROLOGY 33:1360-1370(2012).
