CREM
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Official Full Name
cAMP responsive element modulator -
Overview
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. -
Synonyms
CREM;cAMP responsive element modulator;cAMP-responsive element modulator;hCREM 2;CREM 2beta-a protein;CREM 2alpha-b protein;cAMP response element modulator;inducible cAMP early repressor ICER;ICER;CREM-2;hCREM-2;MGC17881;MGC41893;MGC111110
Recombinant Proteins
- Human
- Mouse
- Chicken
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli
- GST
- His
- Non
- His&Fc&Avi
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CREM-1862H | Recombinant Human CREM Protein, GST-tagged | Wheat Germ | Human | GST |
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| CREM-3900M | Recombinant Mouse CREM Protein | Mammalian Cell | Mouse | His |
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| CREM-5384C | Recombinant Chicken CREM | Mammalian Cell | Chicken | His |
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| CREM-5385C | Recombinant Chicken CREM | Mammalian Cell | Chicken | His |
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| CREM-5386C | Recombinant Chicken CREM | Mammalian Cell | Chicken | His |
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| CREM-5387C | Recombinant Chicken CREM | Mammalian Cell | Chicken | His |
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| CREM-5957C | Recombinant Chicken CREM | Mammalian Cell | Chicken | His |
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| CREM-7283HCL | Recombinant Human CREM 293 Cell Lysate | HEK293 | Human | Non |
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| CREM-7284HCL | Recombinant Human CREM 293 Cell Lysate | HEK293 | Human | Non |
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| CREM-7285HCL | Recombinant Human CREM 293 Cell Lysate | HEK293 | Human | Non |
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| CREM-1973M | Recombinant Mouse CREM Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CREM-1973M-B | Recombinant Mouse CREM Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CREM-2296HF | Recombinant Full Length Human CREM Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 137 amino acids |
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| CREM-3330H | Recombinant Human CREM Protein, His-tagged | E.coli | Human | His |
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| CREM-840H | Recombinant Human CREM Protein, His&GST-tagged | E.coli | Human | His&GST | Met1-Glu182 |
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Involved Pathway
CREM involved in several pathways and played different roles in them. We selected most pathways CREM participated on our site, such as Adrenergic signaling in cardiomyocytes,HTLV-I infection,SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenergic signaling in cardiomyocytes | TPMA,ACTC1B,CACNB4,BCL2A,PLCB2,SLC14A2,CREB3L1,CACNA2D3,CACNA1SB,ATP1A3 |
| SIDS Susceptibility Pathways | SP3,KCNQ1,MAZ,CC2D1A,CDCA7L,TSPYL1,PKNOX1,PLP1,LMX1B,POU2F2 |
| Selenium Metabolism and Selenoproteins | DIO2,TXNRD3IT1,TXNRD2,SELENBP1,SP3,MSRB1,SELT,TRNAU1AP,FBXO17,SELK |
| HTLV-I infection | KAT2B,PPP3R2,SRF,POLD2,XBP1,APC2,IL15,FZD3,WNT6,HLA-DMA |
Protein Function
CREM has several biochemical functions, for example, DNA binding,cAMP response element binding protein binding,core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREM itself. We selected most functions CREM had, and list some proteins which have the same functions with CREM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cAMP response element binding protein binding | DDIT3,CRTC2,CREB3,KCNA3,ATF2,CRTC3,CRTC1A,DAPK3,CRTC1 |
| DNA binding | DLX5A,EME1,HBP1,NKX2.2B,H2AFX,PARP2,PRM1,HOXC9A,HOXD12,ZNF329 |
| core promoter sequence-specific DNA binding | MYOCD,CRY1,CHD2,NFYA,MEOX1,RORA,THRAP3,SP1,MLL1,ESR1 |
| transcription factor activity, sequence-specific DNA binding | NFATC2,HNF1BB,ZNF43,ESRRGB,ENO1,ATF7A,PRRXL1,ELF2A,CLOCKB,HIVEP2A |
| protein binding | CYB5R2,ZCCHC12,RGS1,TRIM33,RPL11,ANKRD45,FCRL4,SRSF10,SKA1,FANCI |
Interacting Protein
CREM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREM here. Most of them are supplied by our site. Hope this information will be useful for your research of CREM.
il2_human_gene;fos_human_gene;il2_human_crem-site_dna-probe;SP100;il17_human_cre-site_dna-probe;Hdac1;HDAC1;DNMT3A;ATXN1;EMP3;UBE2I
Resources
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References
- Khajavi, N; Akbari, M; et al. Role of Somatic Testicular Cells during Mouse Spermatogenesis in Three-Dimensional Collagen Gel Culture System. CELL JOURNAL 16:79-90(2014).
- Huang, YF; Kream, BE; et al. The P2 Promoter of the CREM Gene is Responsive to cAMP-PKA Signaling Pathway in Osteoblastic MC3T3-E1 Cells. JOURNAL OF HARD TISSUE BIOLOGY 20:225-230(2011).
