CPS1
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Official Full Name
carbamoyl-phosphate synthase 1, mitochondrial -
Overview
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate.;This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from;cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants;encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the;mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency,;susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow;transplantation. -
Synonyms
CPS1;carbamoyl-phosphate synthase 1, mitochondrial;carbamoyl phosphate synthetase 1, mitochondrial;carbamoyl-phosphate synthase [ammonia], mitochondrial;carbamoylphosphate synthetase I;CPSASE1
Recombinant Proteins
- Rat
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Yeast
- His
- GST
- His&Fc&Avi
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CPS1-1573R | Recombinant Rat CPS1 Protein | Mammalian Cell | Rat | His |
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| CPS1-1809H | Recombinant Human CPS1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CPS1-3500C | Recombinant Chicken CPS1 | Mammalian Cell | Chicken | His |
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| CPS1-3857M | Recombinant Mouse CPS1 Protein | Mammalian Cell | Mouse | His |
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| CPS1-0486H | Recombinant Human CPS1 protein, His-tagged | E.coli | Human | His | 1354-1500aa |
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| CPS1-1230R | Recombinant Rat CPS1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CPS1-1230R-B | Recombinant Rat CPS1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CPS1-1843H | Recombinant Human CPS1, His-tagged | E.coli | Human | His | 1361-1500 a.a. |
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| CPS1-1941M | Recombinant Mouse CPS1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CPS1-1941M-B | Recombinant Mouse CPS1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Cps1-2724R | Recombinant Rat Cps1 protein, His&Myc-tagged | E.coli | Rat | His&Myc | 1355-1500aa |
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| CPS1-5840H | Recombinant Human CPS1 protein, His-tagged | Yeast | Human | His | 1354-1500aa |
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Involved Pathway
CPS1 involved in several pathways and played different roles in them. We selected most pathways CPS1 participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | ASNS,IL4I1,AGXTB,ADSSL,ALDH4A1,GOT2B,PPAT,ASL2,GLULC,AGXTA |
| Nitrogen metabolism | Car12,CAR13,CAHZ,GLUL,CA4A,GLUD2,GLULA,GLUD1A,CA4B,Car9 |
| Arginine biosynthesis | GLUL,OTC,GLS2,GLULA,GPT2,GOT2A,ASL2,GPT2L,GOT2,ARG1 |
| Carbon metabolism | PDHA1B,PRPS2,MUT,FBP1,ALDOAA,HADHAB,DLAT,MDH1AA,G6PDX,GPIB |
| Metabolic pathways | PDHA1B,GGT1A,GLYCTK,ADH7,ATP6V1D,UQCRC1,IDH3A,SMPD1,CHIA.4,KDSR |
| Biosynthesis of amino acids | MAT2A,PGAM1A,GAPDH,GOT2A,ALDOCB,PFKM,PFKMA,ENO1,CBSA,SDS |
Protein Function
CPS1 has several biochemical functions, for example, ATP binding,calcium ion binding,carbamoyl-phosphate synthase (ammonia) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CPS1 itself. We selected most functions CPS1 had, and list some proteins which have the same functions with CPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipid binding | BAD,SYT14,PACSIN1A,ESYT1,VAMP2,TICAM2,AGAP1,SGIP1,PLEKHA3,PSD4 |
| nucleotide binding | PLK2B,D19ERTD386E,HNRNPH2,SRSF2A,MOV10B.2,RPS6KAL,ATAD1B,RBM38,TUBA8L4,UBE2D1B |
| catalytic activity | APOBEC2A,ALPI.1,SYN2A,LYZ1,PPM1DA,ACSS2L,Amy1,SPTLC3,TDH2,PARP3 |
| metal ion binding | STS,GALNT11,ZFP354B,ZNF606,FTR82,RREB1,ZNF326,TRIT1,ARHGAP29B,FOXP4 |
| ATP binding | PFKFB4,PRKX,DGKB,ALK,GC3,PASK,DCAKD,GAK,FYN,ENTPD2 |
| carbamoyl-phosphate synthase (ammonia) activity | CAD |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | CAD |
| endopeptidase activity | ADAMTS3,KLK1B3,CD46,NCSTN,PARL,PSMB1,KLK1B8,PSMA6,PCSK6,KLK1B4 |
| calcium ion binding | HSPA5,STIM1,OIT3,PPEF1,CIB1,SYT1B,S100A8,PRRG2,PCDHGA5,MYLPFB |
Interacting Protein
CPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPS1.
Sirt5;Amy1;Ywhae;Pgls;Hsd3b7
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References
- Lee, YY; Li, CF; et al. Overexpression of CPS1 is an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy. TUMOR BIOLOGY 35:11097-11105(2014).
- Li, J; Chen, L; et al. Detection of Circulating Tumor Cells in Hepatocellular Carcinoma Using Antibodies against Asialoglycoprotein Receptor, Carbamoyl Phosphate Synthetase 1 and Pan-Cytokeratin. PLOS ONE 9:-(2014).
