CPLX1
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Official Full Name
complexin 1 -
Overview
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis.These proteins bind syntaxin, part of the SNAP receptor.The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. -
Synonyms
CPLX1;complexin 1;complexin-1;CPX I;921-S;Complexin I;CPLX1_HUMAN;CPX-I;CPX1;Synaphin 2;Synaphin-2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Cynomolgus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CPLX1 involved in several pathways and played different roles in them. We selected most pathways CPLX1 participated on our site, such as Acetylcholine Neurotransmitter Release Cycle,Dopamine Neurotransmitter Release Cycle,GABA synthesis, release, reuptake and degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPLX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acetylcholine Neurotransmitter Release Cycle | RAB3AB,PPFIA1,PPFIA4,UNC13B,RERG,SNAP25B,CCDC167,STXBP1A,SNAP25A,CPLX2L |
| Glutamate Neurotransmitter Release Cycle | STXBP1A,SLC1A3A,SNAP25B,SNAP25A,CCDC167,SLC1A7B,ARL6IP5A,ARL6IP5B,BZRAP1,UNC13B |
| Dopamine Neurotransmitter Release Cycle | LIN7C,UNC13B,SYN1,LIN7B,PPFIA4,CCDC167,LIN7A,SYN2,SYN3,RERG |
| Neuronal System | KCNJ14,LIN7C,BZRAP1,KCNG1,KCND2,KCNK10B,NCALDA,KCNAB2,KCNB2,PPFIA4 |
| Serotonin Neurotransmitter Release Cycle | RERG,SYN2,SYN3,PPFIA2,PPFIA4,SYN1,PPFIA1 |
| Neurotransmitter Release Cycle | SNAP25B,SLC1A3B,PPFIA4,RERG,RAB3AA,BZRAP1,PPFIA2,SLC17A7A,LIN7B,SNAP25A |
| GABA synthesis, release, reuptake and degradation | SLC6A11,RAB3AA,RAB3AB,SLC6A1B,CCDC167,SYT1A,SLC6A1A,ABAT,SNAP25B,SLC6A12 |
| Norepinephrine Neurotransmitter Release Cycle | SYT1A,RERG,STXBP1A,RAB3AB,RAB3AA,SNAP25A,PPFIA2,UNC13B,SNAP25B,PPFIA1 |
Protein Function
CPLX1 has several biochemical functions, for example, neurotransmitter transporter activity,syntaxin-1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPLX1 itself. We selected most functions CPLX1 had, and list some proteins which have the same functions with CPLX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neurotransmitter transporter activity | SLC6A15,GABRQ,CPLX3 |
| syntaxin-1 binding | MYO5A,STXBP3A,NSF,RNF40,STXBP1,SYT1,STXBP3,SNAP25,SNAP25B,UNC13A |
Interacting Protein
CPLX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPLX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPLX1.
RXRB;pi3p;IQCB1
Resources
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References
- Stenovec, M; Goncalves, PP; et al. Peptide Hormone Release Monitored From Single Vesicles in "Membrane Lawns" of Differentiated Male Pituitary Cells: SNAREs and Fusion Pore Widening. ENDOCRINOLOGY 154:1235-1246(2013).
- Keino, H; Watanabe, T; et al. Effect of Infliximab on Gene Expression Profiling in Behcet's Disease. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:7681-7686(2011).
