COX6A1
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Official Full Name
cytochrome c oxidase subunit VIa polypeptide 1 -
Overview
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. -
Synonyms
COX6A1;cytochrome c oxidase subunit VIa polypeptide 1;COX6A;cytochrome c oxidase subunit 6A1, mitochondrial;mitochondrial;COX VIa L;COX VIa-L;COX6AL;CX6A1_HUMAN;Cytochrome c oxidase polypeptide VIa liver;Cytochrome c oxidase polypeptide VIa-liver;Cytochrome c oxidase subunit 6A1;Cytochrome c oxidase subunit 6A1 mitochondrial;Cytochrome C oxidase subunit VIa homolog;Cytochrome c oxidase subunit VIA liver;Cytochrome c oxidase subunit VIA-liver;MGC104500;MS412
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Chicken
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COX6A1-1433Z | Recombinant Zebrafish COX6A1 | Mammalian Cells | Zebrafish | His |
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| COX6A1-1753H | Recombinant Human COX6A1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COX6A1-27583TH | Recombinant Human COX6A1 | Wheat Germ | Human | Non | 109 amino acids |
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| COX6A1-3817M | Recombinant Mouse COX6A1 Protein | Mammalian Cells | Mouse | His |
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| COX6A1-4901C | Recombinant Chicken COX6A1 | Mammalian Cells | Chicken | His |
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| COX6A1-4902C | Recombinant Chicken COX6A1 | Mammalian Cells | Chicken | His |
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| COX6A1-7331HCL | Recombinant Human COX6A1 293 Cell Lysate | HEK293 | Human | Non |
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| COX6A1-1915M | Recombinant Mouse COX6A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| COX6A1-1915M-B | Recombinant Mouse COX6A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COX6A1-2010HF | Recombinant Full Length Human COX6A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 109 amino acids |
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| COX6A1-5841H | Recombinant Human COX6A1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| COX6A1-91HF | Recombinant Full Length Human COX6A1 Protein | In Vitro Cell Free System | Human | Full L. 109 amino acids |
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| Cox6a1-927M | Recombinant Mouse Cox6a1 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
COX6A1 involved in several pathways and played different roles in them. We selected most pathways COX6A1 participated on our site, such as Alzheimers disease,Cardiac muscle contraction,Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | COX4I1,NDUFC1,NDUFA9,CASP12,COX5A,LRP1,SNCA,PPP3CA,MAPT,MAPK1 |
| Cardiac muscle contraction | RYR2,COX7A2,COX5AA,TNNC1,SLC8A1,TPMA,CACNA2D1A,ATP1A3,TNNI3,CACNA2D1 |
| Huntingtons disease | NDUFA12,PPIF,MT-ATP6,VDAC2,CASP8,NDUFV1,NDUFA3,NDUFV2,COX7A1,NDUFA6 |
| Metabolic pathways | CYP21A2,DHFRL1,AANAT1,PPCDC,NT5M,DHRS4,HYKK.2,AFMID,B3GNT2B,AZIN2 |
| Generic Transcription Pathway | MED20,GPR19,HBXIP,ZKSCAN5,ZNF839,ZNF302,NRBF2,ZFP90,ZNF740,TEAD3B |
| Metabolism | NHLRC1,CHST9,GLTPA,NAT2,NFYAL,OMD,FAM213B,CYP2C18,NDUFAF3,MED25 |
| Gene Expression | MBD3,POLR3G,MBD3A,ZNF658,ZNF498,PTBP1A,ZNF100,LBH,ZNF548,PRPF8 |
| Electron Transport Chain | SURF1,ATPIF1,COX6B1,UCP3,NDUFC2-KCTD14,COX7C,ATP5L,COX17,SCO1,SLC25A27 |
Protein Function
COX6A1 has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6A1 itself. We selected most functions COX6A1 had, and list some proteins which have the same functions with COX6A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytochrome-c oxidase activity | COX15,COX7A1,COX5AA,COX11,COX6B2,COA6,CYB5A,COX7A2L,COX7B2,COX5B |
Interacting Protein
COX6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6A1.
GRB2;HTT;CLPP
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References
- HUNTSMAN, MM; ISACKSON, PJ; et al. LAMINA-SPECIFIC EXPRESSION AND ACTIVITY-DEPENDENT REGULATION OF 7 GABA(A) RECEPTOR SUBUNIT MESSENGER-RNAS IN MONKEY VISUAL-CORTEX. JOURNAL OF NEUROSCIENCE 14:2236-2259(1994).
