COX17

  • Official Full Name

    COX17 cytochrome c oxidase assembly homolog

  • Overview

    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.

  • Synonyms

    COX17;COX17 cytochrome c oxidase assembly homolog (S. cerevisiae);COX17 (yeast) homolog, cytochrome c oxidase assembly protein , COX17 homolog, cytochrome c oxidase assembly protein (S. cerevisiae) , COX17 homolog, cytochrome c oxidase assembly protei

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Yeast
  • Chicken
  • Rhesus macaque
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • Non
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
COX17-11488H Recombinant Human COX17, GST-tagged E.coli Human GST 1-63a.a.
COX17-448H Recombinant Human COX17 (S. cerevisiae) E.coli Human Non Full L.
COX17-1366Z Recombinant Zebrafish COX17 Mammalian Cell Zebrafish His
COX17-1738H Recombinant Human COX17 Protein, GST-tagged Wheat Germ Human GST
COX17-3810M Recombinant Mouse COX17 Protein Mammalian Cell Mouse His
COX17-449 Recombinant S.cervisiae S.cervisiae COX17 E.coli Yeast Non Full L.
COX17-5641C Recombinant Chicken COX17 Mammalian Cell Chicken His
COX17-984R Recombinant Rhesus monkey COX17 Protein, His-tagged Mammalian Cell Rhesus macaque His
COX17-1911M Recombinant Mouse COX17 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
COX17-1911M-B Recombinant Mouse COX17 Protein Pre-coupled Magnetic Beads HEK293 Mouse
COX17-2000HF Recombinant Full Length Human COX17 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 63 amino acids
COX17-809R Recombinant Rhesus Macaque COX17 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
COX17-809R-B Recombinant Rhesus Macaque COX17 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    COX17 involved in several pathways and played different roles in them. We selected most pathways COX17 participated on our site, such as Electron Transport Chain,Metabolic pathways,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins TMED2,IGFBP6B,B3GNT3,CPA3,EEF1B2,ADAMTS4,BET1,ST6GALNAC1.2,ARSJ,GPR120
    Electron Transport Chain UCP2,COX6C,SURF1,COX6B1,COX15,COX4I1,SLC25A14,SLC25A27,SCO1,COX7A2
    Metabolic pathways FLAD1,NAT2,PLA2G2D,DSE,GOT1,MAPK1IP1L,IMPDH1B,CDS2,COX8A,CNDP1
    Oxidative phosphorylation Atp5g2,ATP6V1E2,ATP5G3A,UQCRC2A,NDUFB7,ATP5F1,NDUFS3,ATP6V0CB,ATP6V0E1,ATP6AP1
    Mitochondrial protein import TIMM9,BCS1L,TIMM22,TIMM17A,TIMM23,SAMM50,TOMM22,TOMM6,DNAJC19,TOMM7

    Protein Function

    COX17 has several biochemical functions, for example, copper chaperone activity,copper ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX17 itself. We selected most functions COX17 had, and list some proteins which have the same functions with COX17. You can find most of the proteins on our site.

    Function Related Protein
    copper chaperone activity ATOX1,ATX1
    copper ion binding HEPH,LOX,ABP1,P2RX4,METTL17,IL1A,APOA4,S100A12,PARK7,HEPHL1A
    protein binding HSPA12B,RNF216,LTBP1,CDK17,LACTB2,KAT5,LGI4,DGCR6L,TTF2,ARHGAP26

    Interacting Protein

    COX17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX17 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX17.

    KATNAL1;PPBP;TP53;HADHB;SUMO2;EEF1A1;UNC119;RBM48;RIF1;COPS6;C14orf1;P

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