COLQ
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Official Full Name
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase -
Overview
This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
COLQ;collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase;acetylcholinesterase collagenic tail peptide;acetylcholinesterase associated collagen;AChE Q subunit;collagenic tail of endplate acetylcholinesterase;EAD;single strand of homotrimeric collagen like tail subunit of asymmetric acetylcholinesterase;Acetylcholinesterase collagen-like tail subunit isoform I;Acetylcholinesterase collagenic tail peptide precursor;Acetylcholinesterase-associated collagen;asymmetric acetylcholinesterase;COLQ_HUMAN;single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COLQ-1525R | Recombinant Rat COLQ Protein | Mammalian Cell | Rat | His |
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| COLQ-1672H | Recombinant Human COLQ Protein, GST-tagged | Wheat Germ | Human | GST |
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| Colq-3061R | Recombinant Rat Colq, His-tagged | E.Coli or Yeast | Rat | His | 458 |
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| COLQ-3759M | Recombinant Mouse COLQ Protein | Mammalian Cell | Mouse | His |
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| COLQ-1182R | Recombinant Rat COLQ Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| COLQ-1182R-B | Recombinant Rat COLQ Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| COLQ-1875M | Recombinant Mouse COLQ Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COLQ-1875M-B | Recombinant Mouse COLQ Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COLQ-2212HF | Recombinant Full Length Human COLQ Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 445 amino acids |
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Involved Pathway
COLQ involved in several pathways and played different roles in them. We selected most pathways COLQ participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with COLQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
COLQ has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COLQ itself. We selected most functions COLQ had, and list some proteins which have the same functions with COLQ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FLAD1,CHEK2,RBM10,ZDHHC17,CD93,CLN5,SIN3A,NR3C2,VPS18,NAT8B |
Interacting Protein
COLQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COLQ here. Most of them are supplied by our site. Hope this information will be useful for your research of COLQ.
Resources
Research Area
Neurotransmitter Associated EnzymesPhosphatases and Regulators
Alzheimer's Disease
Acetylcholine Muscarinic Receptors
Acetylcholine Nicotinic Receptors
Related Services
Related Products
References
- Katarzyna, MZ; Belaya, K; et al. Collagen Q - A potential target for autoantibodies in myasthenia gravis. JOURNAL OF THE NEUROLOGICAL SCIENCES 348:241-244(2015).
- Ohno, K; Ito, M; et al. Collagen Q is a Key Player for Developing Rational Therapy for Congenital Myasthenia and for Dissecting the Mechanisms of Anti-MuSK Myasthenia Gravis. JOURNAL OF MOLECULAR NEUROSCIENCE 53:359-361(2014).
