COASY
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Official Full Name
CoA synthase -
Overview
Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014] -
Synonyms
COASY;CoA synthase;NBP;DPCK;PPAT;UKR1;NBIA6;pOV-2;bifunctional coenzyme A synthase;nucleotide binding protein;phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase;bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- E. coli
- GST
- His
- T7
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
COASY involved in several pathways and played different roles in them. We selected most pathways COASY participated on our site, such as Pantothenate and CoA biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COASY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pantothenate and CoA biosynthesis | PANK4,DPYS,ENPP3,AASDHPPT,BCAT2,VNN2,PANK1B,PANK3,VNN1,PPCS |
| Metabolic pathways | NDUFB4,PI4KA,AKR1B1,CYP2P8,MINPP1A,PLA2G4AA,POLE,MDH1AA,MTHFR,UQCRC2B |
Protein Function
COASY has several biochemical functions, for example, ATP binding,dephospho-CoA kinase activity,pantetheine-phosphate adenylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COASY itself. We selected most functions COASY had, and list some proteins which have the same functions with COASY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MTHFD1B,BLK,ABCD2,MARS,LACE1A,SMC6,DDX11,DDX27,ULK3,PKMYT1 |
| dephospho-CoA kinase activity | DCAKD |
| protein binding | CD46,IFNGR1,SMARCC2,CREM,LTBR,ZBTB17,SYNE3,RRAGA,C21orf2,DAB2 |
Interacting Protein
COASY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COASY here. Most of them are supplied by our site. Hope this information will be useful for your research of COASY.
RPS6KB1;EDC4;RPS6KB2;KRT20;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;VCAM1
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