CNGA4
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Official Full Name
cyclic nucleotide gated channel alpha 4 -
Overview
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 -
Synonyms
CNGA4;cyclic nucleotide gated channel alpha 4;CNCA2, CNGB2, cyclic nucleotide gated channel beta 2;cyclic nucleotide-gated cation channel alpha-4;CNG5;OCNC2;OCNCb;Cgn2;CNCA2;CNG 4;CNG channel alpha 4;CNG4;Cnga4 cyclic nucleotide gated channel alpha 4;CNGB2;Cyclic nucleotide gated cation channel alpha 4;Cyclic nucleotide gated channel beta 2;Cyclic nucleotide gated olfactory channel subunit OCNC2;MGC126168;MGC126169;MGC130316;OCNCBETA;CNG channel alpha-4;CNG-4
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- Rat
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- E.coli
- GST
- His
- His&Fc&Avi
- His&SUMO
Involved Pathway
CNGA4 involved in several pathways and played different roles in them. We selected most pathways CNGA4 participated on our site, such as cAMP signaling pathway,Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNGA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | BRAF,HTR1B,MAPK10,PIK3CD,RAC1,PIK3CG,GHSR,NFATC1,CREB3L3,RAC2 |
| Olfactory transduction | OR51B2,OLFR494,OR6K3,OR1A2,PRKACG,PRKG1,OLFR18,OR4C13,OLFR998,CALM4 |
Protein Function
CNGA4 has several biochemical functions, for example, cAMP binding,cGMP binding,intracellular cAMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNGA4 itself. We selected most functions CNGA4 had, and list some proteins which have the same functions with CNGA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cGMP binding | PRKG1A,CNGA1,CNGA5,PRKG2,PRKG1,PDE6G,PDE11A,PDE5A,PDE6H,PDE6C |
| nucleotide binding | KIAA0430,NIM1,EIF4BA,RBM17,MOV10B.2,AKT2L,NXF1,BOLL,GRSF1,SIK2A |
| cAMP binding | RAPGEF3,BVES,PDE4D,PDE10A,PDE4A,PRKAR1A,CNGA2,PRKAR2B,PRKAR1B,RAPGEF4 |
| ion channel activity | SCNN1G,TRPN1,SCN8AB,KCNF1A,GRIA3A,KCNH5A,KCNC3A,TPC3,HTR3B,SCN12AB |
| intracellular cAMP activated cation channel activity | CNGA3,HCN2,CNGA1,HCN4,CNGA5 |
| intracellular cGMP activated cation channel activity | CNGA2,CNGA5,CNGA1,AQP1,CNGA3 |
| intracellular cyclic nucleotide activated cation channel activity | KCNA10 |
Interacting Protein
CNGA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNGA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNGA4.
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References
- Landry, Y; Gies, JP; et al. Drugs and their molecular targets: an updated overview. FUNDAMENTAL & CLINICAL PHARMACOLOGY 22:1-18(2008).
- Paillart, C; Zhang, K; et al. Cloning and molecular characterization of cGMP-gated ion channels from rod and cone photoreceptors of striped bass (M-saxatilis) retina. VISUAL NEUROSCIENCE 23:99-113(2006).
