CNGA1
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Official Full Name
cyclic nucleotide gated channel alpha 1 -
Overview
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CNGA1;cyclic nucleotide gated channel alpha 1;CNCG, CNCG1;cGMP-gated cation channel alpha-1;CNG1;RCNC1;RCNCa;photoreceptor;cGMP gated cation channel alpha 1;CNCG;CNCG1;CNG 1;CNG channel alpha 1;CNG channel alpha-1;CNG-1;CNGA1_HUMAN;Cyclic nucleotide gated cation channel 1;Cyclic nucleotide gated channel photoreceptor;Cyclic nucleotide-gated cation channel 1;Cyclic nucleotide-gated channel alpha-1;Cyclic nucleotide-gated channel;Interleukin 1 homologue;OTTHUMP00000218675;OTTHUMP00000223313;OTTHUMP00000223314;RCNCalpha;Rod photoreceptor cGMP gated channel subunit alpha;Rod photoreceptor cGMP-gated channel subunit alpha;RP49;interleukin-1 homologue;cyclic nucleotide-gated channel, photoreceptor;rod photoreceptor cGMP-gated channel subuni
Recombinant Proteins
- Rat
- Mouse
- Chicken
- Human
- Bovine
- Mus musculus
- Dog
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
CNGA1 involved in several pathways and played different roles in them. We selected most pathways CNGA1 participated on our site, such as Activation of the phototransduction cascade,Inactivation, recovery and regulation of the phototransduction cascade,Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Visual phototransduction | LRP10,DHRS3,BCO2,GUCA1E,MYO7AA,RBP2A,APOA4B.2,RLBP1B,APOA4B.1,LRP12 |
| Inactivation, recovery and regulation of the phototransduction cascade | SAGB,PPEF1,METAP2A,GRK7,METAP2,METAP1,RLN1,RHOL,NMT1,NMT1B |
| Signal Transduction | ARHGEF1B,FGD4,FST,RHOF,RAMP1,ARHGAP29,PYGO1,EMR4,GDI2,GPR132 |
| Visual signal transduction: Rods | RDH12 |
| cAMP signaling pathway | PLD2,PPP1CC,HTR1B,PIK3R2,ATP2A2,CALML5,RAP1A,PDE4B,PLD1,CALM2 |
| The phototransduction cascade | PPEF1,METAP2,METAP2B,RGS9BP,NMT1A,RLN1,METAP2A,SAGB,NMT1B,METAP1 |
| Activation of the phototransduction cascade | RHOL |
| Phototransduction | CALM2B,RCV1,RGS9A,GUCA1B,PDE6A,RHO,CALM4,GNAT1,GNB4B,GNB1 |
Protein Function
CNGA1 has several biochemical functions, for example, cGMP binding,intracellular cAMP activated cation channel activity,intracellular cGMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNGA1 itself. We selected most functions CNGA1 had, and list some proteins which have the same functions with CNGA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| intracellular cAMP activated cation channel activity | HCN2,CNGA4,HCN4,CNGA3,CNGA5 |
| cGMP binding | PDE10A,PDE6G,CNGA5,PDE6C,PRKG1,CNGA4,CNGA2,PRKG2,PDE2A,PRKG1A |
| intracellular cGMP activated cation channel activity | CNGA2,CNGA4,CNGA5,CNGA3,AQP1 |
| voltage-gated potassium channel activity | KCNC3A,KCNV2,KCNA2B,HCN2,KCNQ2A,KCNAB2B,KCNH6,KCNS3A,KCNH8,KCNH2A |
| protein binding | TRIM69,TLK2,EMP3,PAPOLA,PELO,HTRA2,MBD3,ARIH1,FGF21,PFDN5 |
Interacting Protein
CNGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNGA1.
GRB14;Grb14
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References
- Winkler, PA; Ekenstedt, KJ; et al. A Large Animal Model for CNGB1 Autosomal Recessive Retinitis Pigmentosa. PLOS ONE 8:-(2013).
