CLOCK

  • Official Full Name

    circadian locomotor output cycles kaput

  • Overview

    Circadian rhythms govern many key physiological processes that fluctuate with a period of approximately 24 hours. These processes include the sleep-wake cycle, glucose, lipid and drug metabolism, heart rate, hormone secretion, renal blood flow, and body t

  • Synonyms

    CLOCK;circadian locomotor output cycles kaput;circadian locomoter output cycles protein kaput;mCLOCK;circadian locomoter output cycles kaput;KAT13D;bHLHe8;mKIAA0334;5330400M04Rik

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi&Fc&His
  • His&T7
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLOCK-11340H Recombinant Human CLOCK, GST-tagged E.coli Human GST 1-351a.a.
CLOCK-1459R Recombinant Rat CLOCK Protein Mammalian Cells Rat His
CLOCK-3596M Recombinant Mouse CLOCK Protein Mammalian Cells Mouse His
CLOCK-5488C Recombinant Chicken CLOCK Mammalian Cells Chicken His
CLOCK-5748C Recombinant Chicken CLOCK Mammalian Cells Chicken His
CLOCK-75H Recombinant Human CLOCK, GST-tagged Wheat Germ Human GST
CLOCK-7436HCL Recombinant Human CLOCK 293 Cell Lysate HEK293 Human Non
CLOCK-1117R Recombinant Rat CLOCK Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CLOCK-1117R-B Recombinant Rat CLOCK Protein Pre-coupled Magnetic Beads HEK293 Rat
CLOCK-1526H Recombinant Human CLOCK protein, His & T7-tagged E.coli Human His&T7 Ala34~Ala379
CLOCK-1765M Recombinant Mouse CLOCK Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CLOCK-1765M-B Recombinant Mouse CLOCK Protein Pre-coupled Magnetic Beads HEK293 Mouse
CLOCK-6888HF Recombinant Full Length Human CLOCK Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 846 amino acids

    Involved Pathway

    CLOCK involved in several pathways and played different roles in them. We selected most pathways CLOCK participated on our site, such as Circadian rhythm,Dopaminergic synapse,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLOCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dopaminergic synapse PPP2CB,GNG4,PPP2R5E,GSK3B,GNG5,GRIN2A,DRD1,CALY,TH,AKT2
    Herpes simplex infection MHC2DEB,BLA,POLR2A,LOC100033925,HLA-DRB4,Hc,TAF4B,IFNGR1,NFKBIAB,STAT1B
    Circadian rhythm PRKAB2,CUL1,PRKAG3,NPAS2,CRY2,CSNK1E,RORA,PER2,FBXL3,NR1D1

    Protein Function

    CLOCK has several biochemical functions, for example, DNA binding,E-box binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLOCK itself. We selected most functions CLOCK had, and list some proteins which have the same functions with CLOCK. You can find most of the proteins on our site.

    Function Related Protein
    E-box binding ATOH8,AHR,GATA3,ZEB1,ASCL2,ARNTL2,PER1,ARNTL,TCF4,ASCL1
    protein binding IMP3,PDIA6,PPP1R3C,PADI4,KIAA0146,CDCA4,KCTD1,ATP1B1,VAT1L,UCHL3
    transcription factor activity, sequence-specific DNA binding PBX3B,RAB11FIP4A,ZNF493,ZSCAN4F,KLF10,JUNBA,ZKSCAN6,NR1I3,T,TSC22D3
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding FOSL1,ARNTL,HIST2H3A,MSX1,RBPJL,ATF3,FOSL2,FOSL1A,SFPI1,JDP2
    sequence-specific DNA binding HOXB6B,NR3C2,CEBP1,HOXA6,ENG1B,SIX1,DBX1B,HOXC1A,ESX1,PRRX1
    DNA binding SOX21,ZBTB16A,BRCA1,HIST1H2BN,ZNF45,TBL1XR1,KHDRBS1,HIST1H2AN,PCBP3,ZFP541
    histone acetyltransferase activity KAT6A,NCOA1,KAT7,ATF2,KAT2A,METTL8,CSRP2BP,KAT6B,TAF1,KAT5
    RNA polymerase II core promoter proximal region sequence-specific DNA binding RBPJ,FOXL2,RFX2,OTX2,SREBF1,RFX6,SOX10,NR4A3,ASCL2,HOXA2
    chromatin DNA binding HIST1H1C,THRA,ATOH1,GATA1,HIST1H1B,NKAP,EZH2,GRHL3,SLAMF7,FOXO3

    Interacting Protein

    CLOCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLOCK here. Most of them are supplied by our site. Hope this information will be useful for your research of CLOCK.

    ARNTL;bamB;ARNTL2;mdm2_human_probe;Cry1

    Resources

    Research Area

    Circadian Rhythm Molecules
    Histone Acetyltransferases and Associated Proteins

    References

    • Lau, SKP; Woo, PCY; et al. Discovery of a Novel Coronavirus, China Rattus Coronavirus HKU24, from Norway Rats Supports the Murine Origin of Betacoronavirus 1 and Has Implications for the Ancestor of Betacoronavirus Lineage A. JOURNAL OF VIROLOGY 89:3076-3092(2015).
    • Sheng, WL; Chen, WY; et al. Co-Expression of Two Subtypes of Melatonin Receptor on Rat M1-Type Intrinsically Photosensitive Retinal Ganglion Cells. PLOS ONE 10:-(2015).

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