CLK2

  • Official Full Name

    CDC-like kinase 2

  • Overview

    This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation. [provided by RefSeq, Jul 2008]

  • Synonyms

    CLK2;CDC-like kinase 2;hCLK2;dual specificity protein kinase CLK2;CLK kinase

Recombinant Proteins

  • Human
  • Chicken
  • E.coli
  • Sf9 Insect Cell
  • Insect Cell
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • GST
  • His
  • Non
  • His&SUMO
  • His&B2M
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLK2-11334H Recombinant Human CLK2, GST-tagged E.coli Human GST C-term-300a.a.
CLK2-1005H Recombinant Human CDC-Like Kinase 2, GST-tagged Sf9 Insect Cell Human GST 137-end a.a.
CLK2-1493H Active Recombinant Human CLK2 Protein, GST-tagged Insect Cell Human GST
CLK2-1494H Recombinant Human CLK2 Protein, GST-tagged Wheat Germ Human GST
CLK2-285H Recombinant Human CDC-like Kinase 2, GST-tagged, Active Sf9 Insect Cell Human GST 137-end a.a.
CLK2-2980C Recombinant Chicken CLK2 Mammalian Cell Chicken His
CLK2-7440HCL Recombinant Human CLK2 293 Cell Lysate HEK293 Human Non
CLK2-0392H Recombinant Human CLK2 Protein (R130-D496), Tag Free E.coli Human Non R130-D496
CLK2-0393H Recombinant Human CLK2 Protein (R130-D496), GST tagged E.coli Human GST R130-D496
CLK210047H Recombinant Human CLK2 (136-496) Protein, His-tagged E.coli Human His
CLK2-2204HF Recombinant Full Length Human CLK2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 498 amino acids
CLK2-2703H Recombinant Human CLK2 protein, His-SUMO-tagged E.coli Human His&SUMO 138-499aa
CLK2-2704H Recombinant Human CLK2 protein, His-B2M-tagged E.coli Human His&B2M 138-499aa
CLK2-4343HF Active Recombinant Full Length Human CLK2 Protein, GST-tagged Insect (sf21) Human GST Full L. 1-499

    Involved Pathway

    CLK2 involved in several pathways and played different roles in them. We selected most pathways CLK2 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA processing DDX39,CLASRP,SF3A3,ZFP346,DDX20,HNRPL,HNRNPH1,PTBP2,FAM120B,D19BWG1357E

    Protein Function

    CLK2 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK2 itself. We selected most functions CLK2 had, and list some proteins which have the same functions with CLK2. You can find most of the proteins on our site.

    Function Related Protein
    protein serine/threonine/tyrosine kinase activity AURKA,RPS6KA1,AURKC,ACVR2B,DYRK1AA,DYRK3,MAP2K1,TESK2,DSTYK,DYRK2
    protein serine/threonine kinase activity PIK3R4,DCLK1,OBSCN,ALPK1,RAF1B,CAMKK1B,MAP3K4,ULK1A,PAK2A,MINK1
    ATP binding BTK,ATP8B1,SMC6,ERBB4A,IDH3G,DDX21,VMHCL,CCT8,BMPR1BA,MAT1A
    protein tyrosine kinase activity EPHB2B,BTK,PTK2,TNK1,IGF1RA,ALK,EPHB3A,FGFR4,SHC1,SRC
    protein binding ADAM22,FBXO25,YWHAH,DAP3,ITGA2B,HEY1,KCNE3,ARMC2,KCTD6,ATXN7L3

    Interacting Protein

    CLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK2.

    CLK3;RBM39;SNIP1;YWHAG

    Resources

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