CLEC12A
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Official Full Name
C-type lectin domain family 12, member A -
Overview
CLEC12A, also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family. Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylat -
Synonyms
CLEC12A;C-type lectin domain family 12, member A;C-type lectin domain family 12 member A;CLL 1;MICL;C-type lectin superfamily;C-type lectin protein CLL-1;C-type lectin-like molecule-1;dendritic cell-associated lectin 2;myeloid inhibitory C-type lectin-like receptor;CLL1;CLL-1;DCAL-2;MGC70602
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- HEK293
- CHO
- Wheat Germ
- Human Cell
- In Vitro Cell Free System
- E.coli
- Insect Cell
- His
- Fc
- Fc&Avi
- N-His,C-Avi
- Non
- GST
- His&Myc
Involved Pathway
CLEC12A involved in several pathways and played different roles in them. We selected most pathways CLEC12A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein Function
CLEC12A has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC12A itself. We selected most functions CLEC12A had, and list some proteins which have the same functions with CLEC12A. You can find most of the proteins on our site.
Function | Related Protein |
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carbohydrate binding | NOMO3,ATRNL1,REG1A,CLEC2G,PKD1L3,ZG16,G6PDX,REG1B,REG3G,CLEC18B |
Interacting Protein
CLEC12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC12A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC12A.
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesC-type Lectin Receptors
Leukemia Cancer Stem Cell Markers
C-type Lectin Family
Related Services
Related Products
References
- Hangalapura, BN; van Loo, PF; et al. A NOVEL CLEC12AXCD3 BISPECIFIC ANTIBODY EFFICIENTLY INDUCES T-CELL MEDIATED LYSIS OF CLEC12A+AML BLASTS. HAEMATOLOGICA 99:294-294(2014).
- Gagne, V; Marois, L; et al. Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications. ARTHRITIS RESEARCH & THERAPY 15:-(2013).
Reviews
The effect of immunizing mice with this protein is very good.