CLDN3
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Official Full Name
claudin 3 -
Overview
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
CLDN3;claudin 3;C7orf1, CPETR2;claudin-3;Clostridium perfringens enterotoxin receptor 2;CPE R2;CPE receptor 2;HRVP1;RVP1;ventral prostate.1 like protein;CPE-R 2;CPE-receptor 2;ventral prostate.1-like protein;ventral prostate.1 protein homolog
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Rhesus macaque
- Bovine
- Mus musculus
- Dog
- E.coli
- HEK293
- Mammalian Cells
- Wheat Germ
- Insect Cells
- In Vitro Cell Free System
- Protein Conjugation
- GST
- Non
- His
- His&Fc&Avi
- His&B2M
Involved Pathway
CLDN3 involved in several pathways and played different roles in them. We selected most pathways CLDN3 participated on our site, such as Cell adhesion molecules (CAMs),Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | ARHGAP35,THY1,VASP,VCAM1,CLDN15,GNAI2,MAPK12,JAM2,PIK3R3,CLDN11 |
| Hepatitis C | KRAS,CLDN5,TNF,MAPK8,NRAS,HRAS,PIK3CD,MAPK13,CLDN7,IFNA21 |
| Tight junction interactions | INADL,CLDN23,CLDN7,CLDN4,CLDN20,CLDN16 |
| Cell-Cell communication | JUPA,INADL,F11R.2,PVRL1A,PVRL2L,CLDN7,DSCAM,DCC,KIRREL,ITGB1B.1 |
| Cell-cell junction organization | ANG,CDH10A,PVRL1A,CADM2,CDH9,JUP,CTNND1,CDH8,CDH10,CLDN7 |
| Tight junction | RRAS,PRKCH,RHOAB,MYL2B,PRKCBB,ACTN2,PRKCI,MYH15,SHROOM4,MYH1A |
| Cell adhesion molecules (CAMs) | GLG1,ICAM3,JAM3B,ICAM1,CLDN19,HLA-F,HLA-DRB4,MHC2DCB,NCAM1B,CLDN2 |
| Cell junction organization | TESK1,CDH11,DST,PARVB,CDH13,RSU1,FERMT2,CDH7,CD151,CTNND1 |
Protein Function
CLDN3 has several biochemical functions, for example, identical protein binding,structural molecule activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN3 itself. We selected most functions CLDN3 had, and list some proteins which have the same functions with CLDN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | KRT27,KRT38,MAP7D1,LCE3C,KRTAP3-1,COPG2,SPRR1A,KRT6A,KRT77,KRT79 |
| transmembrane signaling receptor activity | OR4D2,GPR124,OR4N4,LILRB5,FZD3A,IL27RA,LYVE1,Fzd4,CLEC2H,GIPR |
| identical protein binding | NCL,C14orf166,CPT1A,SOX10,ZNF3,CIDEB,GLE1,PARP1,CBY1,P2RX6 |
Interacting Protein
CLDN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN3.
Resources
Research Area
Tight Junction Proteins in Endothelial CellsEpithelial Cell Markers and Intracellular Molecules
Claudins
Tight Junctions
Related Services
Related Products
References
- Ricardo, S; Gerhard, R; et al. Claudin expression in breast cancer: High or low, what to expect?. HISTOLOGY AND HISTOPATHOLOGY 27:1283-1295(2012).
- Meng, J; Greenlee, AR; et al. Sertoli Cell-Specific Deletion of the Androgen Receptor Compromises Testicular Immune Privilege in Mice. BIOLOGY OF REPRODUCTION 85:254-260(2011).
