CITED1
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Official Full Name
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -
Overview
CITED-1 (Cbp/p300-Interacting Transactivator 1)/Melanocyte-specific protein 1 is highly expressed in most of the papillary thyroid carcinoma. It is not expressed in normal tissues except normal breast epithelium. Study shows that this protein functions as a selective coactivator for estrogen-dependent transcription. -
Synonyms
CITED1;Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1;MSG1;cbp/p300-interacting transactivator 1;melanocyte-specific gene 1;melanocyte-specific protein 1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
- T7
- DDK
- Myc
Involved Pathway
CITED1 involved in several pathways and played different roles in them. We selected most pathways CITED1 participated on our site, such as Regulation of nuclear SMAD2/3 signaling,TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CITED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of nuclear SMAD2/3 signaling | CBFB,GSC,FOXH1,NKX2,SKI,MYOD1,SNIP1 |
| TGF-beta Receptor Signaling Pathway | RUNX2A,GIPC1,STK11IP,MEF2AA,CTCF,ZEB1B,HOXD9A,STRAP,NFYBB,VDRB |
Protein Function
CITED1 has several biochemical functions, for example, LBD domain binding,RNA polymerase II transcription coactivator activity,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CITED1 itself. We selected most functions CITED1 had, and list some proteins which have the same functions with CITED1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | TCF7L2,PROX1,ZNF174,SMAD4,AIRE,ZNF567,WNT1,RCOR1,MSX2,GABPA |
| co-SMAD binding | SMAD2,TGIF1,SMAD6,FOXH1,TRIM33,GATA4,SMAD3,USP9X,SMAD1 |
| transcription factor activity, sequence-specific DNA binding | DLX3,ATF4,IRF3,E2F6,HOXA2B,SNAPC2,ZRANB2,PIP4K2AA,MSRB2,ZFP37 |
| protein C-terminus binding | ATP1B1,ECM1,LIG4,CORO1A,TOP2B,MKI67,SNF8,PQBP1,KPNA3,NCL |
| RNA polymerase II transcription coactivator activity | POU3F1,MED12L,PHF17,NCOA1,MED12,SOX12,NEUROD1,ISL1,CREBBP,MYOCD |
| chromatin binding | PRKCB,IFT74,PRMT6,TOP2A,ZFP143,MEIOB,SP110,ORC1L,HDAC4,SKIL |
| protein homodimerization activity | ASGR1,DMRTC2,HHEX,TYRP1,SETMAR,CALCOCO2,PVRL1A,TIMM10,CD200,MGLL |
| protein binding | CD28,CDK2AP1,CLOCKA,SGOL2,APEX1,CYP1A1,CD48,EXOSC3,DTX3L,MED10 |
| LBD domain binding | PROX1,MED1,CITED2 |
Interacting Protein
CITED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CITED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CITED1.
ESR1;JUN;E2;e1a_ade12;ATF2;Twist1;cp24a_human_gene;cp27b_human_gene;TP53
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References
- Jones, S; Prasad, ML; et al. Comparative Evaluation of High-Throughput Small-Core (0.6-mm) and Large-Core (2-mm) Thyroid Tissue Microarray Is Larger Better?. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 136:199-203(2012).
- Nasr, MR; Mukhopadhyay, S; et al. Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: utility of HBME1 combined with CK19 immunostaining. MODERN PATHOLOGY 19:1631-1637(2006).
