CIITA
-
Official Full Name
class II, major histocompatibility complex, transactivator -
Overview
MHC class II (MHC-II) proteins play critical roles in cellular immune responses and their expression is mainly regulated by the non-DNA binding transcription factor CIITA (MHC class II transactivator). CIITA expression is upregulated by IFN-gamma and it i -
Synonyms
CIITA;class II, major histocompatibility complex, transactivator;MHC class II transactivator , MHC2TA;MHC class II transactivator;C2TA;NLR family;acid domain containing;NLRA;nucleotide binding oligomerization domain;leucine rich repeat and acid d
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CIITA-5313H | Recombinant Human CIITA Protein, GST-tagged | Wheat Germ | Human | GST |
|
Involved Pathway
CIITA involved in several pathways and played different roles in them. We selected most pathways CIITA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CIITA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CIITA has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CIITA itself. We selected most functions CIITA had, and list some proteins which have the same functions with CIITA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CIITA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CIITA here. Most of them are supplied by our site. Hope this information will be useful for your research of CIITA.
Resources
Research Area
Multiple Sclerosis and Myelin Related MoleculesConventional/Classical Dendritic Cells
Inflammatory/Monocyte-derived Dendritic Cells
Langerhans and Dermal Dendritic Cells
Dendritic Cell Pathogen Recognition/Uptake
Related Services
Related Products
References
- Surmann, EM; Voigt, AY; et al. Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:357-366(2015).
- Lloyd, MC; Szekeres, K; et al. Class II Transactivator Expression in Melanoma Cells Facilitates T-cell Engulfment. ANTICANCER RESEARCH 35:25-29(2015).
