CHN1

  • Official Full Name

    chimerin (chimaerin) 1

  • Overview

    This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duanes retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

  • Synonyms

    CHN1;chimerin (chimaerin) 1;CHN, Duane retraction syndrome 2 , DURS2;N-chimaerin;ARHGAP2;Chimerin 1 (GTPase activating protein;rho;2);n chimerin;RhoGAP2;A-chimaerin;Alpha-chimerin;CHIN_HUMAN;CHN;N chimaerin;N-chimerin;NC;Rho GTPase-activating protein 2;a2-chimaerin;OTTHUMP00000205333;OTTHUMP00000205334;OTTHUMP00000205335;OTTHUMP00000205339;OTTHUMP00000205340;OTTHUMP00000205342;DURS2

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • Insect Cells
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Fc
  • Non
  • Avi
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CHN1-11192H Recombinant Human CHN1, GST-tagged E.coli Human GST N-term-350a.a.
CHN1-3093H Recombinant Human CHN1 protein, His-tagged E.coli Human His 145-207 aa
CHN1-12244Z Recombinant Zebrafish CHN1 Mammalian Cells Zebrafish His
CHN1-1256H Recombinant Human CHN1 Protein, GST-Tagged Wheat Germ Human GST
CHN1-1378R Recombinant Rat CHN1 Protein Mammalian Cells Rat His
CHN1-2163C Recombinant Chicken CHN1 Mammalian Cells Chicken His
CHN1-240H Recombinant Human CHN1, Gly&Pro tagged Insect Cells Human Fc 2-459 a.a.
CHN1-241H Recombinant Human CHN1, His-GST tagged Insect Cells Human Fc 2-459 a.a.
CHN1-001HCL Recombinant Human CHN1 cell lysate Insect Cells Human Non
CHN1-002HCL Recombinant Human CHN1 cell lysate Insect Cells Human Non
CHN1-0255H Recombinant Human CHN1 protein, His&GST-tagged Insect Cells Human GST&His 2-459 a.a.
CHN1-1036R Recombinant Rat CHN1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CHN1-1036R-B Recombinant Rat CHN1 Protein Pre-coupled Magnetic Beads HEK293 Rat
CHN1-2197H Recombinant Human CHN1 protein Insect Cells Human Non Ala2-Phe459
CHN1-3211HF Recombinant Full Length Human CHN1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 459 amino acids
CHN1-3230H Recombinant Human CHN1 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
CHN1-3758H Recombinant Human CHN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Chn1-383M Recombinant Mouse Chn1 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
CHN1-7843H Recombinant Human CHN1 protein, His-tagged E.coli Human His
CHN1-7844H Recombinant Human CHN1 protein, GST-tagged E.coli Human GST

    Involved Pathway

    CHN1 involved in several pathways and played different roles in them. We selected most pathways CHN1 participated on our site, such as Regulation of RAC1 activity,Rho GTPase cycle,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of RAC1 activity ABR,DOCK6,ARHGAP17,RALBP1,DEF6,PREX2,RAP1GDS1,EPS8,ARHGAP9,SPATA13
    Signal Transduction NRP2,GPR177,CDON,IFT172,NEDD8L,CDC37,KAL1,RIT2,XK,GPR18
    Rho GTPase cycle GDI2,ARHGAP29B,DLC1,ARHGEF1A,FAM13A,OPHN1,STARD13,ARHGAP17A,ARHGEF16,FAM13B
    Signaling by Rho GTPases ARHGAP20,ARHGAP31,STARD13,IQGAP3,CHN2,ARHGAP9,ARHGAP6,ARAP1,ARHGAP28,TAGAPA

    Protein Function

    CHN1 has several biochemical functions, for example, GTPase activator activity,SH3/SH2 adaptor activity,ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHN1 itself. We selected most functions CHN1 had, and list some proteins which have the same functions with CHN1. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity GRB7,GRB10,SH2B2,ARHGAP1,SH3BGRL,SKAP2,HSH2D,STAP1,SOCS2,SH3BGR
    protein binding RRP8,KLHDC4,MGRN1,GORAB,EPB42,CDK4,AHCY,TMEM147,RTN4A,FABP2
    metal ion binding ITGB1BP3,ALKBH7,KDM3B,ZFP36L1A,HIC2,ARMC1L,PRDM1,ZNF410,B4GALT3,KDM4D
    GTPase activator activity TBC1D8,RASAL3,RACGAP1,LRRK2,AGAP5,RGS17,DOCK1,TBC1D16,STARD8,RGS5
    ephrin receptor binding EFNB2B,EFNA3,EFNA5B,EFNA2,SHC1,ANKS1B,CBL,SRC,NTRK1,EPHA4

    Interacting Protein

    CHN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHN1.

    NCK2;HEMK1;CDK5R1;ERBB2;RPS3A;GTF3C1;MAPK8IP2

    Resources

    References

    • Iwata, R; Ohi, K; et al. RacGAP alpha 2-Chimaerin Function in Development Adjusts Cognitive Ability in Adulthood. CELL REPORTS 8:1257-1264(2014).
    • Ferreiro, JF; Rouhigharabaei, L; et al. Integrative Genomic and Transcriptomic Analysis Identified Candidate Genes Implicated in the Pathogenesis of Hepatosplenic T-Cell Lymphoma. PLOS ONE 9:-(2014).

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