CHMP4C
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Official Full Name
CHMP4C charged multivesicular body protein 4C [ Homo sapiens ] -
Overview
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). -
Synonyms
Charged multivesicular body protein 4c;CHM4C_HUMAN;CHMP4c;Chromatin-modifying protein 4c;hSnf7-3;hVps32-3;SNF7 homolog associated with Alix 3;SNF7-3;Vacuolar protein sorting-associated protein 32-3;Vps32-3
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CHMP4C involved in several pathways and played different roles in them. We selected most pathways CHMP4C participated on our site, such as Budding and maturation of HIV virion,Cellular responses to stress,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHMP4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIV Life Cycle | NMT1,VPS37A,ELL,PSIP1,SSRP1,CDK9,NMT2,TCEB3,RCC1,PDCD6IP |
| HIV Infection | NPM1,AP1B1,PACS1,SSRP1,ELL,TCEB3,CHMP4B,APOBEC3G,RCC1,CDK9 |
| Endocytosis | TGFBR1B,VPS4B,HSC70,KITB,CAPZB,CAPZA1B,RAB22A,CHMP1B,ERBB3,PLD1 |
| Infectious disease | NMT1,KPNA5,CHMP4B,PDCD6IP,NMT2,IPO5,LTF,AP1G1,DOCK2,CPSF4 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | SNF8,VPS37A,STAM2,CHMP4B |
| Cellular responses to stress | UVRAG,WIPI1,DNAJC2,EED,RPS19BP1,LAMTOR1,UBN1,RING1,PRDX3,HSPA13 |
| Budding and maturation of HIV virion | PDCD6IP,PPIA,gag,VPS37A,CHMP4B |
| Disease | OS9,SYT2,MTRR,AP2B1,KPNA4,STX1B,NA,RLBP1,AP1B1,AP1G1 |
Protein Function
CHMP4C has several biochemical functions, for example, protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHMP4C itself. We selected most functions CHMP4C had, and list some proteins which have the same functions with CHMP4C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SYMPK,RBMX2,CARF,SLC6A20B,UBE2Q1,RASSF1,YIF1A,Tnfrsf23,SH3RF2,DALRD3 |
| protein homodimerization activity | DPY30,SNX6,ZHX3,DHDPSL,TERFA,PRTFDC1,ENPP1,SMAD1,RNF17,ABCG2 |
Interacting Protein
CHMP4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHMP4C here. Most of them are supplied by our site. Hope this information will be useful for your research of CHMP4C.
USP8;128872;USP54;STAMBP;PDCD6IP;IGHA1
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