CHKB
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Official Full Name
choline kinase beta -
Overview
Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. -
Synonyms
CHKB;choline kinase beta;CHKL, choline kinase like;choline/ethanolamine kinase;CHETK;Chetk-beta;Chkb choline kinase beta;Chkb protein;CHKB_HUMAN;CHKL;Choline kinase-like;Choline kinase-like protein;choline/ethanolamine kinase beta;Choline/ethanolamine kinase, beta;CK;CK/EK;CK/EK-beta;CKB;CKEKB;EK;EKB;Ethanolamine kinase;Ethanolamine kinase beta;Ethanolamine kinase, beta;MDCMC
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHKB-1243H | Recombinant Human CHKB Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CHKB-1374R | Recombinant Rat CHKB Protein | Mammalian Cell | Rat | His |
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| CHKB-26715TH | Recombinant Human CHKB | Wheat Germ | Human | Non | 395 amino acids |
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| CHKB-3399M | Recombinant Mouse CHKB Protein | Mammalian Cell | Mouse | His |
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| CHKB-35H | Recombinant Human CHKB protein | E.coli | Human | Non | 395aa |
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| CHKB-5818Z | Recombinant Zebrafish CHKB | Mammalian Cell | Zebrafish | His |
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| CHKB-7534HCL | Recombinant Human CHKB 293 Cell Lysate | HEK293 | Human | Non |
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| CHKB-1032R | Recombinant Rat CHKB Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CHKB-1032R-B | Recombinant Rat CHKB Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CHKB-1645M | Recombinant Mouse CHKB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CHKB-1645M-B | Recombinant Mouse CHKB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Chkb-1726M | Recombinant Mouse Chkb protein, His-tagged | E.coli | Mouse | His | Phe238~Ser394 |
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| CHKB-3202HF | Recombinant Full Length Human CHKB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 395 amino acids |
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| CHKB-4578H | Recombinant Human CHKB Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| CHKB-775H | Recombinant Human CHKB Protein, His-tagged | E.coli | Human | His | Phe238-Ser395 |
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| CHKB-78HF | Recombinant Full Length Human CHKB Protein | In Vitro Cell Free System | Human | Full L. 395 amino acids |
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| Chkb-885M | Recombinant Mouse Chkb Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
CHKB involved in several pathways and played different roles in them. We selected most pathways CHKB participated on our site, such as Choline metabolism in cancer,Fatty Acid Beta Oxidation,Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipid metabolism | CPNE1,CHKA,CDS1,SACM1LB,AWAT2,PTPMT1,PEMT,CPNE7,CEPT1,ARF3 |
| Metabolism of lipids and lipoproteins | CYP2AD6,PLIN2,YAP1,CYP4T8,G0S2,MED22,MED23,ACOT10,BRSK2,SCP2B |
| Metabolism | EBP,PPM1LB,NUDT4A,SULT1ST6,NUDT3B,HIBADH,NDUFAF2,GLB1L,GSTK1,CHKA |
| Metabolic pathways | GBA2,CSGALNACT1,ADC,EBP,PDHA1B,AMY1A,NME2B.2,APRT,ALDH3B2,LIPT2 |
| Glycerophospholipid metabolism | AGPAT4,GPD1,PLA2G2F,LYCAT,MBOAT2,ADPRM,AGPAT6,EPT1,PTDSS1,PPAP2B |
| Choline metabolism in cancer | GPCPD1,TSC2,RAC1,RAF1,MAPK3,SLC22A2,MAPK1,PLA2G4A,MTOR,SLC22A3 |
| Fatty Acid Beta Oxidation | CPT1B,DECR1,ECI1,CPT2,CRAT,SLC25A20,CPT1A |
| Glycerophospholipid biosynthesis | CHAT,CDIPT,AGPAT6,CDS1,DGAT1B,AWAT1,MGLL,AGPAT2,AWAT2,PLA2G16 |
Protein Function
CHKB has several biochemical functions, for example, ATP binding,choline kinase activity,ethanolamine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHKB itself. We selected most functions CHKB had, and list some proteins which have the same functions with CHKB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NLRP2,PLK4,PHKG2,NUAK1,MCM3L,WEE2,ACACA,TRPV4,DNAJA1,GRK7 |
| ethanolamine kinase activity | ETNK1,CHKA,ETNK2 |
| choline kinase activity | CHKA |
Interacting Protein
CHKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHKB here. Most of them are supplied by our site. Hope this information will be useful for your research of CHKB.
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References
- Yang, L; Roh, YS; et al. Transforming Growth Factor Beta Signaling in Hepatocytes Participates in Steatohepatitis Through Regulation of Cell Death and Lipid Metabolism in Mice. HEPATOLOGY 59:483-495(2014).
- Gruber, J; Too, WCS; et al. Balance of human choline kinase isoforms is critical for cell cycle regulation Implications for the development of choline kinase-targeted cancer therapy. FEBS JOURNAL 279:1915-1928(2012).
