CGNL1
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Official Full Name
CGNL1 cingulin-like 1 [ Homo sapiens ] -
Overview
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
Cgnl1;CGNL1_HUMAN;Cingulin like 1;Cingulin-like protein 1;FLJ14957;JACOP;Junction-associated coiled-coil protein;KIAA1749;MGC138254;Paracingulin
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CGNL1-11150H | Recombinant Human CGNL1, His-tagged | E.coli | Human | His | C-term-350a.a. |
Involved Pathway
CGNL1 involved in several pathways and played different roles in them. We selected most pathways CGNL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CGNL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CGNL1 has several biochemical functions, for example, motor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CGNL1 itself. We selected most functions CGNL1 had, and list some proteins which have the same functions with CGNL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| motor activity | MYO1H,DNAIC2,DYNLT3,DYNLL1,DYNLL2,MYO5A,MYH15,MYO7A,DNAHC8,MYH6 |
Interacting Protein
CGNL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CGNL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CGNL1.
APC;p29991-pro_0000037946;YWHAG;YWHAE;WNK1
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References
- Chung, PJK; Chi, LM; et al. MicroRNA-205 Targets Tight Junction-related Proteins during Urothelial Cellular Differentiation. MOLECULAR & CELLULAR PROTEOMICS 13:2321-2336(2014).
- Guillemot, L; Guerrera, D; et al. MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly. MOLECULAR BIOLOGY OF THE CELL 25:1995-2005(2014).
