CFC1
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Official Full Name
cripto, FRL-1, cryptic family 1 -
Overview
This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in this gene can cause autosomal visceral heterotaxy. This protein is involved in left-right asymmetric morphogenesis during organ development. -
Synonyms
CFC1;cripto, FRL-1, cryptic family 1;cryptic protein;CRYPTIC;HTX2;CFC 1;CR 1;Cripto 1;Cripto FRL 1 cryptic family 1;Cryptic family 1;Cryptic gene;FLJ77897;FRL 1;MGC133213;OTTHUMP00000204816;cryptic family protein 1;CFC1B;DTGA2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian cells
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
CFC1 involved in several pathways and played different roles in them. We selected most pathways CFC1 participated on our site, such as Developmental Biology,Regulation of signaling by NODAL,Signaling by NODAL, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | CDK8,NRTN,CAP1,EFNA2A,KALRN,DNM1,FGF18B,DPYSL5B,LGI1B,KCNQ2 |
| Regulation of signaling by NODAL | TDGF1,ACVR1C,LEFTY1 |
| Signaling by NODAL | LEFTY1,PCSK6,ACVR1C,GDF1,TDGF1,DRAP1,FOXH1 |
Protein Function
CFC1 has several biochemical functions, for example, molecular_function,nodal binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFC1 itself. We selected most functions CFC1 had, and list some proteins which have the same functions with CFC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | GM10147,MXRA7,C20orf7,HAUS6,GRRP1,LRRC45,SAP130A,GAGE2C,MTMR11,DNAHC8 |
| nodal binding | ACVR1C |
Interacting Protein
CFC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CFC1.
Resources
Research Area
Early Mesodermal Lineage MarkersEctodermal Lineage Markers
Mesodermal Lineage Markers
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References
