CFB
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Official Full Name
complement factor B -
Overview
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. -
Synonyms
CFB;complement factor B;BF;FB;BFD;GBG;CFAB;PBF2;AHUS4;FBI12;H2-Bf;FLJ54899;C3 proactivator;C3/C5 convertase;C3 proaccelerator;OTTHUMP00000029283;properdin factor B;B-factor, properdin;glycine-rich beta glycoprotein;glycine-rich beta-glycoprotein
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Rhesus macaque
- E.coli
- HEK293
- Wheat Germ
- Insect Cells
- Mammalian Cells
- Human Serum
- In Vitro Cell Free System
- GST
- His
- MBP
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
CFB involved in several pathways and played different roles in them. We selected most pathways CFB participated on our site, such as Complement and coagulation cascades,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C4BP,MASP2,CFI,C8G,CFD,Serpina1b,C4BPB,BDKRB2,Serpina1c,SERPING1 |
| Staphylococcus aureus infection | FCGR2A,ITGB2L,C1QB,C1S,CFH,FCGR1A,HLA-DRB4,HLA-DQA1,C5,FCGR4 |
Protein Function
CFB has several biochemical functions, for example, complement binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CFB itself. We selected most functions CFB had, and list some proteins which have the same functions with CFB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| complement binding | CD59,C8A,C8G,CD46,CR2 |
| serine-type endopeptidase activity | F9B,F9,Acr,HTRA2,TMPRSS11B,PRSS45,KLK1B3,KLK1B16,HGFA,GZMM |
Interacting Protein
CFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFB here. Most of them are supplied by our site. Hope this information will be useful for your research of CFB.
vco3_najka;RPA2;LAMC3;d-mannose;ALB;Nedd1
Resources
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References
- Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).
- Yamamoto, K; Takeuchi, T; et al. Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: The HIKARI randomized, placebo-controlled trial. MODERN RHEUMATOLOGY 24:552-560(2014).
