CFB

  • Official Full Name

    complement factor B

  • Overview

    Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

  • Synonyms

    CFB;complement factor B;BF;FB;BFD;GBG;CFAB;PBF2;AHUS4;FBI12;H2-Bf;FLJ54899;C3 proactivator;C3/C5 convertase;C3 proaccelerator;OTTHUMP00000029283;properdin factor B;B-factor, properdin;glycine-rich beta glycoprotein;glycine-rich beta-glycoprotein

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Zebrafish
  • Rhesus macaque
  • E.coli
  • HEK293EBNA2
  • Wheat Germ
  • Insect Cell
  • Mammalian Cell
  • HEK293
  • Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)
  • HEK293T
  • Mammalian cells
  • In Vitro Cell Free System
  • GST
  • His
  • His&GST
  • His&MBP
  • Non
  • Myc&DDK
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
CFB-11132H Recombinant Human CFB, GST-tagged E.coli Human GST 573-761a.a.
CFB-1164M Recombinant Mouse CFB Protein, His-tagged E.coli Mouse His 23-761 a.a.
CFB-1161H Recombinant Human CFB Protein, His-Tagged HEK293EBNA2 Human His
CFB-1162H Recombinant Human CFB Protein, GST-Tagged Wheat Germ Human GST
CFB-141H Recombinant Human CFB protein, His-tagged Insect Cell Human His 26-259 a.a.
CFB-2106H Recombinant Human CFB protein, His & GST-tagged E.coli Human His&GST Gly35~Asn160
Cfb-2107M Recombinant Mouse Cfb protein, His-tagged E.coli Mouse His Val32~Asp157
Cfb-2108R Recombinant Rat Cfb protein, His-tagged E.coli Rat His Asn269~Val382
Cfb-2109R Recombinant Rat Cfb protein, His & GST-tagged E.coli Rat His&GST Val34~Asp159
Cfb-2110R Recombinant Rat Cfb protein, His & MBP-tagged E.coli Rat His&MBP Val34~Asp159
CFB-26760TH Recombinant Human CFB, His-tagged E.coli Human His 77-764 a.a.
CFB-26762TH Recombinant Human CFB, His-tagged Human His Full L.
CFB-444H Recombinant Human complement factor B, His-tagged E.coli Human His
CFB-8924Z Recombinant Zebrafish CFB Mammalian Cell Zebrafish His
CFB-Bb-2479H Recombinant human CFB-Bb, His-tagged E.coli Human His
CFB-7558HCL Recombinant Human CFB 293 Cell Lysate HEK293 Human Non
CFB-104H Native Human Factor B Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II) Human Non
Cfb-1085M Recombinant Mouse Cfb Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
CFB-1382H Recombinant Human CFB Protein (Tyr573-Leu761), N-His tagged E.coli Human His Tyr573-Leu761
CFB-2186H Recombinant Human CFB Protein (Thr26-Leu764), C-His tagged Mammalian cells Human His Thr26-Leu764
CFB-3292HF Recombinant Full Length Human CFB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 764 amino acids
CFB-334H Recombinant Human CFB Protein, His-tagged HEK293 Human His Met1-Leu764
CFB-583H Recombinant Human CFB Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CFB-583H-B Recombinant Human CFB Protein Pre-coupled Magnetic Beads HEK293 Human
CFB-755H Recombinant Human CFB Protein, His-tagged E.coli Human His Lys260-Leu764
CFB-756H Recombinant Human CFB Protein, His-tagged E.coli Human His Gly35-Asn160
CFB-757R Recombinant Rhesus monkey CFB Protein, His-tagged E.coli Rhesus macaque His Asn270-Thr388
Cfb-758M Recombinant Mouse Cfb Protein, His-tagged E.coli Mouse His Val32-Asp157
Cfb-759M Recombinant Mouse Cfb Protein, His-tagged E.coli Mouse His Thr25-Arg258
CFB-834HFL Recombinant Full Length Human CFB Protein, C-Flag-tagged Mammalian cells Human Flag Full L.

    Involved Pathway

    CFB involved in several pathways and played different roles in them. We selected most pathways CFB participated on our site, such as Complement and coagulation cascades,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades KLKB1,SERPINA1,F10,PLAU,KNG1,CD59,C7,F3,F13B,MASP1
    Staphylococcus aureus infection CFI,HLA-DRB1,ITGB2L,Hc,PTAFR,FCGR1,C1S,HLA-DPA1,HLA-DMB,HLA-DQA2

    Protein Function

    CFB has several biochemical functions, for example, complement binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CFB itself. We selected most functions CFB had, and list some proteins which have the same functions with CFB. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase activity TMPRSS13B,PRSS58,MASP1,HABP2,KLK14,PLAUA,KLK1B3,CFD,KLKB1,PRSS23
    complement binding CR2,C8G,CD46,CD59,C8A

    Interacting Protein

    CFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFB here. Most of them are supplied by our site. Hope this information will be useful for your research of CFB.

    vco3_najka;RPA2;LAMC3;d-mannose;ALB;Nedd1

    Resources

    Research Area

    Alternative Complement Pathway
    Complement Regulatory Proteins

    References

    • Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).
    • Yamamoto, K; Takeuchi, T; et al. Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: The HIKARI randomized, placebo-controlled trial. MODERN RHEUMATOLOGY 24:552-560(2014).

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