CEP290
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Official Full Name
centrosomal protein 290kDa -
Overview
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. -
Synonyms
CEP290;centrosomal protein 290kDa;centrosomal protein of 290 kDa;3H11Ag;BBS14;cancer/testis antigen 87;CT87;FLJ13615;JBTS5;Joubert syndrome 5;KIAA0373;LCA10;Meckel syndrome;type 4;MKS4;nephrocystin 6;NPHP6;POC3;POC3 centriolar protein homolog (Chlamydomonas);rd16;SLSN6;Bardet-Biedl syndrome 14 protein;CE290_HUMAN;CTCL tumor antigen se2 2;FLJ21979;JBTS6;Meckel syndrome, type 4;Monoclonal 3H11 antigen;Nephrocystin-6;POC3 centriolar protein homolog;Prostate cancer antigen T21;SLSN6 1, 2, 5;Tumor antigen se2-2;nephrocytsin-6;OTTHUMP00000242341;CTCL tumor antigen se2-2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CEP290-11112H | Recombinant Human CEP290, His-tagged | E.coli | Human | His | 869-1103a.a. | |
| CEP290-1134H | Recombinant Human CEP290 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CEP290-7640Z | Recombinant Zebrafish CEP290 | Mammalian Cells | Zebrafish | His |
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| CEP290-3231HF | Recombinant Full Length Human CEP290 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 164 amino acids |
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Involved Pathway
CEP290 involved in several pathways and played different roles in them. We selected most pathways CEP290 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEP290 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Anchoring of the basal body to the plasma membrane | CSNK1D,TTBK2,TMEM216,FBF1,TUBB4B,MAPRE1B,SCLT1,CEP57,MAPRE1,TMEM67 |
| Centrosome maturation | NUMA1,CEP63,HAUS2,ODF2B,CEP57,DCTN1,DCTN2,CDK11A,MAPRE1A,CSNK1E |
| Cell Cycle, Mitotic | KIF18A,CLASP1A,NEK9,LIN37,NUP50,MYCA,KIF20A,ERCC6L,HIST2H3C,HIST4H4 |
| Loss of Nlp from mitotic centrosomes | CEP78,CLASP1A,ODF2,CEP57,MAPRE1A,ODF2B,DCTN1A,CEP70,CKAP5,CEP72 |
| Cell cycle | SMC4,CETN2,CEP78,ATM,NUMA1,SGOL1,ORC5,RBL1,FKBP6,KNTC1 |
| Loss of proteins required for interphase microtubule organizationfrom the centrosome | MAPRE1B,CKAP5,CEP78,NEDD1,CEP70,CEP135,CEP164,DCTN1A,NINL,CCP110 |
| Assembly of the primary cilium | TUBG1,DYNLL2B,WDR35,CEP70,CCT4,ARL13B,RP2,IFT81,TCTEX1D1,CCT3 |
| G2/M Transition | LIN37,CEP152,NINL,CLASP1,CEP135,CEP70,TUBG1,CEP78,HAUS2,LIN9 |
Protein Function
CEP290 has several biochemical functions, for example, NOT microtubule minus-end binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CEP290 itself. We selected most functions CEP290 had, and list some proteins which have the same functions with CEP290. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ACOT8,FOXP2,C1QTNF1,SKAP1,ADRA2C,PSMD2,LDB3,IL2RG,COPS5,SNRPB |
Interacting Protein
CEP290 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEP290 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEP290.
CCP110;CEP97;CEP76;ZNF423;CEP131;CCDC13
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