CENPP
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Official Full Name
centromere protein P -
Overview
CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM;117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006;(PubMed 16622420)). -
Synonyms
CENPP;centromere protein P;CENP P;RP11 19J3.3;FLJ33928;RP11-19J3.3;OTTHUMP00000021661;CENP-P
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- Wheat Germ
- E.coli
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
CENPP involved in several pathways and played different roles in them. We selected most pathways CENPP participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Chromosome Maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromosome Maintenance | MIS18A,CENPW,CENPL,SMARCA5,TINF2,HJURP,OIP5,RBBP7,RBBP4,PANE1 |
| Mitotic Metaphase and Anaphase | SPC25,CENPE,PANE1,KNTC1,ZW10,VRK2,SPC24,NDEL1A,NDC80,CENPH |
| Mitotic Anaphase | CENPN,MLF1IP,MIS12,SPC25,VRK2,WAPAL,VRK1,NDEL1A,ZW10,KNTC1 |
| Cell Cycle, Mitotic | NCAPH2,CCP110,FGFR1OP,APITD1,SGOL2,CDCA5,TCTN2,SGOL1,FOXM1,SPC25 |
| Deposition of new CENPA-containing nucleosomes at the centromere | CENPH,CENPN,CENPQ,CENPI,OIP5,HJURP,CENPL,RBBP4,CENPK,CENPC1 |
| M Phase | NDEL1A,NIPBLA,ITGB3BP,SETB,CTDNEP1B,NDC80,CENPH,SKA2,NUDC,NCAPG |
| Cell cycle | CUL1A,WEE1,NEK9,FKBP6,NIPBL,CENPA,NDC80,RAD50,GINS1,YWHAQ |
| Mitotic Prometaphase | NDEL1B,CENPQ,NSL1,PANE1,PDS5A,WAPAL,RANGAP1B,INCENP,SGOL1,CENPO |
Protein Function
CENPP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPP itself. We selected most functions CENPP had, and list some proteins which have the same functions with CENPP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CRLF1,REPS1,AXIN1,CSRP3,C16orf72,IFT20,TESK2,SIGIRR,ADAM8,ZFP932 |
Interacting Protein
CENPP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPP here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPP.
CENPO;80125;RPIA;GOLGA2;NHLH1;KLC3;TEX11
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References
- Mahler, M; Fritzler, MJ; et al. Autoantibodies to the mitochondrial RNA processing (MRP) complex also known as Th/To autoantigen. AUTOIMMUNITY REVIEWS 14:254-257(2015).
- Mahler, M; Satoh, M; et al. Autoantibodies to the Rpp25 Component of the Th/To Complex are the Most Common Antibodies in Patients with Systemic Sclerosis without Antibodies Detectable by Widely Available Commercial Tests. JOURNAL OF RHEUMATOLOGY 41:1334-1343(2014).
