CENPJ
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Official Full Name
centromere protein J -
Overview
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] -
Synonyms
CENPJ;centromere protein J;LAP;CPAP;LIP1;BM032;MCPH6;SASS4;SCKL4;Sas-4;CENP-J;LAG-3-associated protein;LYST-interacting protein 1;LYST-interacting protein LIP1;LYST-interacting protein LIP7;centrosomal P4.1-associated protein
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CENPJ-11097H | Recombinant Human CENPJ, GST-tagged | E.coli | Human | GST | C-term-306a.a. | |
| CENPJ-1118H | Recombinant Human CENPJ Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CENPJ-3287M | Recombinant Mouse CENPJ Protein | Mammalian Cells | Mouse | His |
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| CENPJ-7583HCL | Recombinant Human CENPJ 293 Cell Lysate | HEK293 | Human | Non |
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| CENPJ-1579M | Recombinant Mouse CENPJ Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CENPJ-1579M-B | Recombinant Mouse CENPJ Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CENPJ-3321HF | Recombinant Full Length Human CENPJ Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 372 amino acids |
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| CENPJ-466H | Recombinant Human CENPJ Protein, His-tagged | E.coli | Human | His | Met1~Asn207 |
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| Cenpj-467M | Recombinant Mouse Cenpj Protein, His-tagged | E.coli | Mouse | His |
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Involved Pathway
CENPJ involved in several pathways and played different roles in them. We selected most pathways CENPJ participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPJ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | RUVBL2,CCNB2,PSMC3IP,ARF1,CDC20,YWHAZ,CENPN,NIPBL,ERCC6L,DPF1 |
| Centrosome maturation | DCTN1A,CEP78,MAPRE1B,TUBG2,TUBG1,MAPRE1,NDE1,TUBGCP2,DCTN2,CEP164 |
| Cell Cycle, Mitotic | DNA2,KIF20A,CEP152,NUDC,GINS1,CEP70,NUP50,DPF1,ARPP19,BLZF1 |
| Loss of Nlp from mitotic centrosomes | ODF2B,PCM1,CCP110,NDE1,CKAP5,MAPRE1B,CEP152,SSNA1,MAPRE1,MAPRE1A |
| Loss of proteins required for interphase microtubule organizationfrom the centrosome | SDCCAG8,NEDD1,MAPRE1,DCTN1A,ODF2B,TUBG1,HAUS2,CKAP5,NDE1,CEP290 |
| Anchoring of the basal body to the plasma membrane | OFD1,TMEM216,FGFR1OP,CEP57,MAPRE1A,TUBB4B,BBS13,MARK4,CEP72,HAUS2 |
| G2/M Transition | TCTN2,PCM1,NDE1,DCTN1,MYBL2,CEP78,LIN37,CEP70,MAPRE1,DYNC1I2 |
| Assembly of the primary cilium | CCT5,EXOC8,CEP164,CEP89,MAPRE1,LZTFL1,TUBG1,CLASP1A,NEDD1,BBS9 |
Protein Function
CENPJ has several biochemical functions, for example, protein binding,protein domain specific binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPJ itself. We selected most functions CENPJ had, and list some proteins which have the same functions with CENPJ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tubulin binding | STMN4,RABGAP1,ATF5,AGTPBP1,GPAA1,MTAP4,TTLL4,EML1,IFT81,STMN4L |
| protein domain specific binding | TACC3,RARA,TJP1,ICA1L,HIST2H4,TUBB,STXBP1,ZBTB16,VAPA,PRKCZ |
| protein kinase binding | VDAC1,SFN,CDKN2D,CNTLN,KCNA5,TNNI3,PTEN,RNF138,MAVS,SUFU |
| protein binding | C1QTNF8,GPS1,SIPA1L2,ZNF10,RBPMS,KRT14,NCL,BCL2L15,G3BP2,LMO3 |
Interacting Protein
CENPJ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPJ here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPJ.
CEP135;STIL
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References
- Song, G; Hu, CJ; et al. New Centromere Autoantigens Identified in Systemic Sclerosis Using Centromere Protein Microarrays. JOURNAL OF RHEUMATOLOGY 40:461-468(2013).
- Hanke, K; Becker, MO; et al. Anticentromere-A and Anticentromere-B Antibodies Show High Concordance and Similar Clinical Associations in Patients with Systemic Sclerosis. JOURNAL OF RHEUMATOLOGY 37:2548-2552(2010).
