CDX2

  • Official Full Name

    caudal type homeobox 2

  • Overview

    This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major;regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in;early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal;inflammation and tumorigenesis.

  • Synonyms

    CDX2;caudal type homeobox 2;caudal type homeo box transcription factor 2 , CDX3;homeobox protein CDX-2;caudal-type homeobox protein 2;caudal type homeobox transcription factor 2;caudal type homeo box transcription factor 2;CDX3;CDX-3

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi&Fc&His
  • GST&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
CDX2-11075H Recombinant Human CDX2, His-tagged E.coli Human His 1-180a.a.
CDX2-1835H Recombinant Human CDX2 protein, GST-tagged E.coli Human GST 1-180 aa
CDX2-1083H Recombinant Human CDX2 Protein, GST-Tagged Wheat Germ Human GST
CDX2-27917TH Recombinant Human CDX2 Wheat Germ Human Non 313 amino acids
CDX2-3242M Recombinant Mouse CDX2 Protein Mammalian Cells Mouse His
CDX2-5884C Recombinant Chicken CDX2 Mammalian Cells Chicken His
CDX2-7602HCL Recombinant Human CDX2 293 Cell Lysate HEK293 Human Non
CDX2-1186H Recombinant Human CDX2 Protein (Met1-Gln313), N-GST tagged E.coli Human GST Met1-Gln313
CDX2-1552M Recombinant Mouse CDX2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CDX2-1552M-B Recombinant Mouse CDX2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CDX2-3265HF Recombinant Full Length Human CDX2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 313 amino acids
CDX2-600H Recombinant Human CDX2 Protein, His/GST-tagged E.coli Human GST&His Met1~Gln313
CDX2-75HF Recombinant Full Length Human CDX2 Protein In Vitro Cell Free System Human Full L. 313 amino acids

    Involved Pathway

    CDX2 involved in several pathways and played different roles in them. We selected most pathways CDX2 participated on our site, such as Incretin synthesis, secretion, and inactivation,Metabolism of proteins,Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Incretin synthesis, secretion, and inactivation DPP4,PCSK1,GPR120,GRP,GPR119,SLC38A8,SPCS3,O3far1
    Peptide hormone metabolism INHBAA,SLC30A6,BCHE,MBOAT4,CPN1,DPP4,EXOC8,SLC38A8,CGB7,CPA3
    Metabolism of proteins PFDN6,CGB5,TOMM7,ACE,NSMCE2,CTSG,GAS6,C8orf84,GALNT5,IGFBP5A

    Protein Function

    CDX2 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,transcription corepressor activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDX2 itself. We selected most functions CDX2 had, and list some proteins which have the same functions with CDX2. You can find most of the proteins on our site.

    Function Related Protein
    transcription corepressor activity CTCF,DNMT3B,NR0B1,MECP2,ATF3,CREG1,YY1,KDM5B,CBFA2T2,TBL1Y
    transcription factor activity, sequence-specific DNA binding VAV1,CEBPD,RARGA,ETV5B,ZNF493,RFX5,SFPI1,KLF9,SOX13,NFIL3
    RNA polymerase II distal enhancer sequence-specific DNA binding SFPQ,H2AFZ,ESRRB,REL,ARX,NFATC1,MED12,NR5A2,PBX3,PROP1
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISX,ETV7,PCGF6,ZC3H8,E4F1,FEZF2,ZBTB4,SNAI3,MITF,ZNF350

    Interacting Protein

    CDX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDX2.

    MEP1A;cdx2_human_gene

    Resources

    Research Area

    Cancer Stem Cell Transcription Factors
    Epithelial Stem Cell Transcription Factors
    Embryonic and Induced Pluripotent Stem Cell Markers
    Trophoblast Stem Cell Markers
    Apical-basal Polarity Effectors

    References

    • Agaimy, A; Lell, M; et al. 'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation. HISTOPATHOLOGY 66:182-191(2015).
    • Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).

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