CDT1
-
Official Full Name
chromatin licensing and DNA replication factor 1 -
Overview
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011] -
Synonyms
CDT1;chromatin licensing and DNA replication factor 1;DUP;RIS2;DNA replication factor Cdt1;Double parked, Drosophila, homolog of
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDT1-11073H | Recombinant Human CDT1, GST-tagged | E.coli | Human | GST | 195-546a.a. | |
| CDT1-105H | Recombinant Human CDT1 protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 546 a.a. |
|
| CDT1-27915TH | Recombinant Human CDT1, His-tagged | E.coli | Human | His | 416-546 a.a. |
|
| CDT1-3240M | Recombinant Mouse CDT1 Protein | Mammalian Cells | Mouse | His |
|
|
| CDT1-7604H | Recombinant Human CDT1 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| CDT1-7604HCL | Recombinant Human CDT1 293 Cell Lysate | HEK293 | Human | Non |
|
|
| CDT1-1550M | Recombinant Mouse CDT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| CDT1-1550M-B | Recombinant Mouse CDT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| CDT1-575HF | Recombinant Full Length Human CDT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 546 amino acids |
|
| CDT1-9663HFL | Recombinant Full Length Human CDT1 protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
Involved Pathway
CDT1 involved in several pathways and played different roles in them. We selected most pathways CDT1 participated on our site, such as Activation of the pre-replicative complex,Assembly of the pre-replicative complex,Association of licensing factors with the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of the pre-replicative complex | DBF4,MCM8,CDK2,MCM10 |
| DNA Replication | POLE4,RFC5,DNA2,GMNN,MCM7,RNASEH1,MCM6L,RPA3,GINS4,POLD1 |
| Cell Cycle, Mitotic | GORASP2,STAG1,CSNK2A2,SPC25,CSNK1D,PMF1,SSNA1,B9D2,DPF1,CDK4 |
| DNA Replication Pre-Initiation | GMNN,MCM10,DBF4 |
| Assembly of the pre-replicative complex | E2F3,E2F1,MCM8,GMNN,E2F2 |
| CDT1 association with the CDC6:ORC:origin complex | MCM8,GMNN |
| Cell cycle | USO1,RBBP4,HJURP,MAPRE1,RUVBL2,CCND3,SMC1A,YWHAQ,HDAC5,MIS18BP1 |
| Association of licensing factors with the pre-replicative complex | E2F2,E2F3,E2F1,GMNN |
Protein Function
CDT1 has several biochemical functions, for example, DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDT1 itself. We selected most functions CDT1 had, and list some proteins which have the same functions with CDT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STX8,MNAT1,WDR74,TNIK,ARHGAP17,POLL,STX4,ALOX15,TTC8,MAK |
| DNA binding | DERL3,SALL3,GM14476,PGR,SET,FOXJ1B,ZFP580,UBN1,ARID4A,ZFP827 |
Interacting Protein
CDT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDT1.
GMNN;MCM6;CDK2;CDC6
Resources
Related Services
Related Products
References
- Kroeger, PT; Shoue, DA; et al. Knockdown of SCFSkp2 Function Causes Double-Parked Accumulation in the Nucleus and DNA Re-Replication in Drosophila Plasmatocytes. PLOS ONE 8:-(2013).
- Yanagita, E; Kamoshida, S; et al. Immunohistochemistry-based Cell Cycle Detection (iCCD): A Novel System to Visualize Cell Kinetics on Formalin-fixed Paraffin-embedded Tissues. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 36:769-773(2012).
