CDS1
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Official Full Name
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -
Overview
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. -
Synonyms
CDS1;CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1;phosphatidate cytidylyltransferase 1;CDP DAG synthase 1;CDP DG synthetase 1;CDP diacylglycerol synthase (phosphatidate cytidylyltransferase) 1;CDP diacylglycerol synthase 1;CDP diglyceride pyrophosphorylase 1;CDP diglyceride synthetase 1;CDP-DAG synthase 1;CDP-DG synthase 1;CDP-diacylglycerol synthase 1;CDP-diglyceride pyrophosphorylase 1;CDP-diglyceride synthase 1;CDS 1;CDS;CDS1_HUMAN;CTP:phosphatidate cytidylyltransferase 1;CDP-DG synthetase 1;CDP-diglyceride synthetase 1;CTP:phosphatidate cytidylyltransf
Recombinant Proteins
- Human
- Rat
- Mouse
- Solanum tuberosum (Potato)
- S.cerevisiae
- Mus musculus
- Arabidopsis thaliana
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
CDS1 involved in several pathways and played different roles in them. We selected most pathways CDS1 participated on our site, such as CDP-diacylglycerol biosynthesis,Glycerophospholipid biosynthesis,Glycerophospholipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | BCAT2,B3GNT2B,RRM2B,AKR1B1,FUT2,PDHA1,ENPP3,CYP24A1,ASMT,ALOX12E |
| Glycerophospholipid metabolism | PPAP2C,DGKZ,DGKAA,PLA2G5,PCYT1BB,LPCAT4,PEMT,LCAT,PLD1A,PLA2G1B |
| Phosphatidylinositol signaling system | MTMR1,IMPAD1,PIK3CA,PIK3C2G,MTMR7A,PTENB,MTMR14,MTMR1B,CALM2,ITPKA |
| Metabolism | CKMB,MTF1,GSTO2,AFMID,AWAT2,NQO1,NAGS,SLC27A5,OMD,NAMPT |
| Phospholipid metabolism | CPNE6,CPNE1,CHKA,SACM1LB,CEPT1A,ABHD3,PITPNB,PHOSPHO1,CPNE3,PNPLA8 |
| Metabolism of lipids and lipoproteins | CYP24A1,CYP2N13,CYP11B1,PNPLA8,GLTPA,COL4A3BP,CETP,ACSF3,YAP1,SACM1LA |
| CDP-diacylglycerol biosynthesis | GPAT2,AGPAT1,AGPAT6,AGPAT2,GK5 |
| Glycerophospholipid biosynthesis | CEPT1A,DGAT1B,PLB1,CEPT1,SLC44A5B,ABHD3,CDIPT,AWAT2,PNPLA8,CPNE6 |
Protein Function
CDS1 has several biochemical functions, for example, diacylglycerol cholinephosphotransferase activity,phosphatidate cytidylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDS1 itself. We selected most functions CDS1 had, and list some proteins which have the same functions with CDS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidate cytidylyltransferase activity | CDS2,TAMM41 |
| diacylglycerol cholinephosphotransferase activity | CHPT1,CEPT1 |
Interacting Protein
CDS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDS1.
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References
- Fields, KA; Hackstadt, T; et al. Evidence for the secretion of Chlamydia trachomatis CopN by a type III secretion mechanism. MOLECULAR MICROBIOLOGY 38:1048-1060(2000).
- Zhou, BBS; Chaturvedi, P; et al. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. JOURNAL OF BIOLOGICAL CHEMISTRY 275:10342-10348(2000).
- Andreev, OA; Borejdo, J; et al. Interaction of the heavy and light chains of cardiac myosin subfragment-1 with F-actin. CIRCULATION RESEARCH 81:688-693(1997).
