CDK5RAP3
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Official Full Name
CDK5 regulatory subunit associated protein 3 -
Overview
CDK5 regulatory subunit-associated protein 3 (Cdk5rap3) is a recently described regulator for Cdk5 activity through interaction with CDK5R1. It may also have a role in cell proliferation. Recent studies have shown Cdk5rap3 to have a crucial role in regulating apoptosis induced by genotoxic stress by interacting with the G2/M DNA damage checkpoint. Expression of Cdk5rap3 is considered ubiquitous, and has been observed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. -
Synonyms
CDK5RAP3;CDK5 regulatory subunit associated protein 3;CDK5 regulatory subunit-associated protein 3;C53;FLJ13660;HSF 27;IC53;ischemic heart CDK5 activator binding protein C53;LXXLL/leucine zipper containing ARFbinding protein;LZAP;MST016;OK/SW cl.114;ischemic heart CDK5 activator-binding protein C53;LXXLL/leucine-zipper-containing ARFbinding protein;HSF-27;OK/SW-cl.114
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Rhesus macaque
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CDK5RAP3 involved in several pathways and played different roles in them. We selected most pathways CDK5RAP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5RAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CDK5RAP3 has several biochemical functions, for example, MDM2/MDM4 family protein binding,NF-kappaB binding,cyclin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5RAP3 itself. We selected most functions CDK5RAP3 had, and list some proteins which have the same functions with CDK5RAP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STX3,KCNG3,AKR1B10,ABL2,RNF135,GH1,TRIM25,MAP3K9,ABCA1,ARSA |
| ubiquitin-like protein ligase binding | CEBPB,DDRGK1,VCP,USP13,TRIP4 |
| MDM2/MDM4 family protein binding | PPARA,TRP53,RFWD3,PSME3,CAV1,CDKN2A |
| mitogen-activated protein kinase binding | MAPKAPK5,GTF2I,PLCB4,PTPRJ,EP300,ATF7,TPR,DUSP2,NBR1,MAPK7 |
| protein kinase binding | CALM3,DNAJA3,FZD5,LATS1,MAML1,LAX1,CCNA2,MAP3K1,RACGAP1,CCNL1B |
| cyclin binding | CUL3,CDK4,CDK12,CDK13,FBXW7,CDK14,INCA1,CDK2,HDAC3,PTCH1 |
| NF-kappaB binding | ANXA4,BRMS1,HDAC1,NFKBIA,GSK3B,NFKBID,RPS3,HIF1AN,HDAC2,PSMA6 |
Interacting Protein
CDK5RAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5RAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5RAP3.
FKBP6;TSPYL4;RELA;Ufl1;51492850;hin1l_human;567160;BANF1;SMNDC1;UFL1;IGKC;IGHA1
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References
- Xie, P; Wei, FY; et al. Quantitative PCR Measurement of tRNA 2-Methylthio Modification for Assessing Type 2 Diabetes Risk. CLINICAL CHEMISTRY 59:1604-1612(2013).
- Lee, WC; Kan, D; et al. Suppression of Extensive Neurofilament Phosphorylation Rescues alpha-Internexin/Peripherin-Overexpressing PC12 Cells from Neuronal Cell Death. PLOS ONE 7:-(2012).
