CDK14
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Official Full Name
cyclin-dependent kinase 14 -
Overview
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 (PubMed;11313143)). -
Synonyms
CDK14;cyclin-dependent kinase 14;PFTAIRE protein kinase 1 , PFTK1;PFTAIRE1;hPFTAIRE1;PFTAIRE protein kinase 1;cell division protein kinase 14;serine/threonine-protein kinase PFTAIRE-1;PFTK1;KIAA0834
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- GST
- His
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDK14-116H |
Active Recombinant Human CDK14/CyclinY, GST-tagged
|
Sf9 Insect Cell | Human | GST |
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| CDK14-180H | Recombinant Human CDK14, GST-tagged | Sf9 Insect Cell | Human | GST |
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| CDK14-3194M | Recombinant Mouse CDK14 Protein | Mammalian Cell | Mouse | His |
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| CDK14-6824Z | Recombinant Zebrafish CDK14 | Mammalian Cell | Zebrafish | His |
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| CDK14-1517M | Recombinant Mouse CDK14 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CDK14-1517M-B | Recombinant Mouse CDK14 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CDK14-3158H | Recombinant Human CDK14 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Cdk14-4814M | Recombinant Mouse Cdk14 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CDK14-725H | Recombinant Human CDK14 Protein, His-tagged | E.coli | Human | His | Tyr135-Phe419 |
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Involved Pathway
CDK14 involved in several pathways and played different roles in them. We selected most pathways CDK14 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | HOXA11,RXRA,PAX7,HIST1H3I,HMGA2,NFKBIZ,ZBTB17,MET,LYL1,PML |
Protein Function
CDK14 has several biochemical functions, for example, ATP binding,cyclin binding,cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK14 itself. We selected most functions CDK14 had, and list some proteins which have the same functions with CDK14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase activity | ERBB3A,TRIOA,LTK,BSK146,ROCK2A,GRK7A,PTK2AA,TNIKB,PRKAB1A,PIK3CA |
| cyclin-dependent protein serine/threonine kinase activity | CDKL3,CDK9,CDK3,CDK10,CDK17,CDK12,CDK6,CDKL1,MOK,CDK15 |
| nucleotide binding | SNRPB2,TRA2B,SFRS3A,PRKCHB,NT5C3L,MATR3,RAVER2,TIA1,MYH9A,MXC |
| protein serine/threonine kinase activity | MAPK8A,MARK4,PRKACAB,ACVR2B,SBK1,ZAK,MAP2K2,WNK2,PKZ,AKT3 |
| protein kinase activity | NPR1A,PRKCHA,MAPK14A,EPHA4,PRKCBB,SNRKA,ARAF,NRBP2,TSSK5,EIF2AK2 |
| cyclin binding | PFTK1,CDK5RAP3,CDK12,CDK13,MDFIC,USP2,CDK4,PTCH1,CDKN1A,CDK2 |
| ATP binding | KIF2C,TBK1,PTK7,MYO6A,BAZ1B,PTK2B,ATP13A,RAD51C,DYNC1H1,CBWD2 |
| transferase activity | CD38,PRKAB1B,PRKAB1A,NMRK2,ELOVL7A,PANK1A,LIPT2,PRMT9,AANAT1,HYKK.2 |
Interacting Protein
CDK14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK14.
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References
- Aoshiba, K; Tsuji, T; et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 65:1053-1062(2013).
- Capobianco, G; Marras, V; et al. P16 immunostaining and HPV testing in histological specimens from the uterine cervix. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 34:227-230(2013).
