CDK11B
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Official Full Name
cyclin-dependent kinase 11B -
Overview
PITSLRE, alternatively known as cell division kinase 11 (CDK11), is the result of duplication of the CDK11 gene (1). CDK11A and CDK11B encode nearly identical serine/threonine protein kinases, PITSLREB and PITSLREA respectively, both belonging to the p34C -
Synonyms
CDK11B;cyclin-dependent kinase 11B;CDC2L1, cell division cycle 2 like 1 (PITSLRE proteins);CDK11 p46;CDK11 p58;CDK11 p110;PITSLREA;p58 CLK-1;CDC-related protein kinase p58;cell division protein kinase 11B;cell division cycle 2-like protein kina
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDK11B-127H | Recombinant Human CDK11B, GST-tagged | Sf9 Cells | Human | GST |
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| CDK11B-1300R | Recombinant Rat CDK11B Protein | Mammalian Cells | Rat | His |
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| CDK11B-1932Z | Recombinant Zebrafish CDK11B | Mammalian Cells | Zebrafish | His |
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| CDK11B-5130H | Recombinant Human CDK11B Protein, GST-tagged | Wheat Germ | Human | GST |
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| CDK11B-723H | Recombinant Human CDK11B Protein, His-tagged | E.coli | Human | His | Phe438-Arg724 |
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| CDK11B-958R | Recombinant Rat CDK11B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| CDK11B-958R-B | Recombinant Rat CDK11B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
CDK11B involved in several pathways and played different roles in them. We selected most pathways CDK11B participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Centrosome maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK11B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G2/M Transition | TUBGCP3,DCTN1,NINL,CKAP5,CEP135,MAPRE1B,CEP70,MAPRE1,CCP110,LIN37 |
| Cell Cycle, Mitotic | CP110,CDKN1B,CENPP,CENPN,LEMD3,NDEL1B,CSNK2A2,CEP70,NUPL2,USO1 |
| Centrosome maturation | TUBB4B,PCM1,MAPRE1B,DYNC1I2,HAUS2,TUBGCP5,OFD1,CDK11A,SDCCAG8,DYNC1H1 |
| Mitotic G2-G2/M phases | TUBGCP2,LIN37,FOXM1,TUBGCP3,CDK11A,LIN52,TUBG2,NUMA1,TUBGCP5,TUBGCP4 |
| Recruitment of mitotic centrosome proteins and complexes | TUBGCP5,TUBGCP2,NUMA1,CDK11A,TUBG2,TUBGCP3,TUBGCP4 |
| Cell cycle | DCTN2,UIMC1,NIPBLB,KNTC1,CENPL,SGOL2,SSNA1,CLIP1,CDC20,CDK1 |
Protein Function
CDK11B has several biochemical functions, for example, ATP binding,cyclin-dependent protein serine/threonine kinase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK11B itself. We selected most functions CDK11B had, and list some proteins which have the same functions with CDK11B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NEK1,ABCA1,QARS,EPHB2,DDX49,ITPKC,PRKACAA,ABCD3A,ABCD2,MYO7AA |
| poly(A) RNA binding | TRNAU1AP,ARL6IP4,SNIP1,NAP1L4,RTCA,MTDH,DDX28,HNRNPA0,FASTKD2,CCDC137 |
| protein binding | UBASH3B,LYRM2,NR1H2,GSTO1,PAX5,ABLIM1,SP100,EPHA4,C19orf80,COG8 |
| protein serine/threonine kinase activity | ACVR1,CAMK2A,SGK1,PHKG1B,TAF1,CHEK1,ACVR1L,MYLK4,ROCK1,PRKACAA |
| cyclin-dependent protein serine/threonine kinase activity | CDK1,CDK17,CDK18,CDK20,PFTK1,CDK7,CDKL2,CDK19,CDK5,CDK11A |
| protein kinase activity | FYNB,RPS6KA3A,GRK1,TBK1,TEK,PKDCCA,PDK4,CAMK2D1,PRKAA1,MAPKAPK2 |
Interacting Protein
CDK11B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK11B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK11B.
KAT7;PAK1;EIF3F;RNPS1;TPPP;MSN;CCND3;RPS27A;AP2M1
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References
- Kamal, A; Reddy, VS; et al. Synthesis of imidazo[2,1-b][1,3,4]thiadiazole-chalcones as apoptosis inducing anticancer agents. MEDCHEMCOMM 5:1718-1723(2014).
- Griffin, D; Liu, XF; et al. Expression of Progesterone Receptor Membrane Component-2 Within the Immature Rat Ovary and Its Role in Regulating Mitosis and Apoptosis of Spontaneously Immortalized Granulosa Cells. BIOLOGY OF REPRODUCTION 91:-(2014).
