CDH23
-
Official Full Name
cadherin-related 23 -
Overview
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Alternative splice variants encoding different isoforms have been described. -
Synonyms
CDH23;cadherin-related 23;cadherin related 23 , cadherin like 23 , DFNB12, USH1D;cadherin-23;cadherin related family member 23;CDHR23;Age related hearing loss 1;Ahl 1;Ahl;Ahl1;Bob;Bobby;Bus;Bustling;Cadherin 23;Cadherin23;CDH 23;Mdfw;Modifier of deaf waddler;nmf112;nmf181;nmf252;Otocadherin;USH 1D;USH1 D;USH1D;Waltzer;cadherin-like 23;OTTHUMP00000020837;OTTHUMP00000020838;cadherin-related family member 23
Recombinant Proteins
- Human
- Zebrafish
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDH23-11038H | Recombinant Human CDH23, GST-tagged | E.coli | Human | GST | 1-352a.a. | |
| CDH23-471H | Recombinant Human CDH23 Protein, His-tagged | E.coli | Human | His | His34~Phe236 | |
| CDH23-0986H | Recombinant Human CDH23 Protein | Wheat Germ | Human | Non |
|
|
| CDH23-0987H | Recombinant Human CDH23 Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| CDH23-12819Z | Recombinant Zebrafish CDH23 | Mammalian Cells | Zebrafish | His |
|
|
| CDH23-1293R | Recombinant Rat CDH23 Protein | Mammalian Cells | Rat | His |
|
|
| CDH23-3148HF | Recombinant Full Length Human CDH23 Protein | In Vitro Cell Free System | Human | Full L. 531 amino acids |
|
|
| CDH23-429H | Recombinant Human CDH23 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
|
| CDH23-951R | Recombinant Rat CDH23 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| CDH23-951R-B | Recombinant Rat CDH23 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
Involved Pathway
CDH23 involved in several pathways and played different roles in them. We selected most pathways CDH23 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CDH23 has several biochemical functions, for example, calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH23 itself. We selected most functions CDH23 had, and list some proteins which have the same functions with CDH23. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | ITPR3,KCNIP3B,SYT16,SYT5A,MYL9B,HEG,KCNIP3A,MMP15,SYT1A,PITPNM3 |
| protein binding | PMM2,MEF2A,DRAM1,ADSS,WNT3A,PFDN5,CCDC116,IQUB,TELO2,PRKAR2A |
Interacting Protein
CDH23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH23 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH23.
Dlg4
Resources
Related Services
Related Products
References
- Tang, PC; Watson, GM; et al. Cadherin-23 May Be Dynamic in Hair Bundles of the Model Sea Anemone Nematostella vectensis. PLOS ONE 9:-(2014).
- Lagziel, A; Overlack, N; et al. Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D. MOLECULAR VISION 15:1843-1857(2009).
