CDH10
-
Official Full Name
cadherin 10, type 2 (T2-cadherin) -
Overview
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the proteins homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. -
Synonyms
CDH10;cadherin 10, type 2 (T2-cadherin);cadherin-10;T2-cadherin
Recombinant Proteins
- Human
- Mouse
- Chicken
- Mus musculus
- CHO
- E.coli
- Mammalian Cells
- HEK293
- Fc
- His
- Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDH10-41H |
Active Recombinant Human CDH10 protein, Fc-tagged
|
CHO | Human | Fc | Glu23-Ala613 |
|
| CDH10-26741TH | Recombinant Human CDH10, His-tagged | E.coli | Human | His | 228-514 a.a. |
|
| CDH10-3163M | Recombinant Mouse CDH10 Protein | Mammalian Cells | Mouse | His |
|
|
| CDH10-7144C | Recombinant Chicken CDH10 | Mammalian Cells | Chicken | His |
|
|
| CDH10-1501M | Recombinant Mouse CDH10 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
|
| CDH10-1501M-B | Recombinant Mouse CDH10 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
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| CDH10-2216H | Recombinant Human CDH10 protein, His-tagged | HEK293 | Human | His | Gly 55 - Ala 613 |
|
| RFL21111GF | Recombinant Full Length Chicken Cadherin-10(Cdh10) Protein, His-Tagged | E.coli | Chicken | His | Full L. Full Length of Mature Protein (55-789) |
|
| RFL31940MF | Recombinant Full Length Mouse Cadherin-10(Cdh10) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length of Mature Protein (55-788) |
|
Involved Pathway
CDH10 involved in several pathways and played different roles in them. We selected most pathways CDH10 participated on our site, such as Adherens junctions interactions,Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell-cell junction organization | JUP,CLDN23,CLDN4,CDH18A,INADL,CADM2,CDH4,CDH7,CDH10A,CDH12 |
| Adherens junctions interactions | CTNNB1,CDH3,CDH24,JUP,CDH6,CDH10A,CDH13,CTNND1,CTNNA1,CDH7 |
| Cell junction organization | CDH13,PVRL1A,INADL,FBLIM1,CDH12A,RSU1,LIMS1,CDH11,PLECA,CDH12 |
| Cell-Cell communication | LIMS1,CDH13,KIRREL3,CDH24,FERMT2,DSCAML1,JUP,CDH2,CDH12A,CDH8 |
Protein Function
CDH10 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH10 itself. We selected most functions CDH10 had, and list some proteins which have the same functions with CDH10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | LETM1,CABP1,PCDH2G13,PCDH2AB3,SRR,CANT1A,MATN3,CAPNS1,PCDH2G16,PCDH2G7 |
Interacting Protein
CDH10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH10.
PTN;COPS6;Cdh1;CTNNB1
Resources
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References
- An, CH; Je, EM; et al. Frameshift Mutations of Cadherin Genes DCHS2, CDH10 and CDH24 Genes in Gastric and Colorectal Cancers with High Microsatellite Instability. PATHOLOGY & ONCOLOGY RESEARCH 21:181-185(2015).
- Ahn, JW; Kim, HS; et al. Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers. GENOME MEDICINE 6:-(2014).
