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CDH10

Official Full Name

cadherin 10, type 2 (T2-cadherin)
Overview

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the proteins homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance.
Synonyms

CDH10; cadherin 10, type 2 (T2-cadherin); cadherin-10; T2-cadherin;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Gallus gallus (Chicken)
Human
Mouse
Mus musculus (Mouse)

Source

CHO
E.coli
E.coli expression system
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CDH10-41H	Active Recombinant Human CDH10 protein, Fc-tagged	CHO	Fc	Glu23-Ala613	Inquiry
Human	CDH10-26741TH	Recombinant Human CDH10, His-tagged	E.coli	His	228-514	Inquiry
Human	CDH10-2216H	Recombinant Human CDH10 protein, His-tagged	HEK293	His	Gly 55 - Ala 613	Inquiry
Mouse	CDH10-3163M	Recombinant Mouse CDH10 Protein	Mammalian Cell	His		Inquiry
Mouse	CDH10-1501M	Recombinant Mouse CDH10 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	CDH10-1501M-B	Recombinant Mouse CDH10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Gallus gallus (Chicken)	RFL21111GF	Recombinant Full Length Chicken Cadherin-10(Cdh10) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (55-789)	Inquiry
Mus musculus (Mouse)	RFL31940MF	Recombinant Full Length Mouse Cadherin-10(Cdh10) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (55-788)	Inquiry
Chicken	CDH10-7144C	Recombinant Chicken CDH10	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CDH10 involved in several pathways and played different roles in them. We selected most pathways CDH10 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adherens junctions interactions	CTNNB2;CDH12;CDH10A;CADM2B;CDH11;CTNNB1;ANG;CDH24;CDH6
Cell junction organization	LIMS1;CD151;INADL;CADM2A;JUP;TESK1;CTNND1;CDH2;CDH4
Cell-Cell communication	CDH24;KIRREL;PVRL1A;PARVB;CTNND1;CLDN23;SIRPB1;CLDN4;KIRRELB
Cell-cell junction organization	CDH6;CADM2B;CDH7;PVRL1A;CDH17;CDH10;CDH18A;F11R.2;CDH10A

CDH10 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH10 itself. We selected most functions CDH10 had, and list some proteins which have the same functions with CDH10. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	PVALB2;ADAMTS13;SLC25A24;GRIN1;NCL;PCDH2G28;RASGRP3;EMR2;PADI1

CDH10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH10.

PTN; COPS6; Cdh1; CTNNB1

Research Area

Cadherins

Cadherin Superfamily

An, CH; Je, EM; et al. Frameshift Mutations of Cadherin Genes DCHS2, CDH10 and CDH24 Genes in Gastric and Colorectal Cancers with High Microsatellite Instability. PATHOLOGY & ONCOLOGY RESEARCH 21:181-185(2015).

Ahn, JW; Kim, HS; et al. Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers. GENOME MEDICINE 6:-(2014).