CDC14A

  • Official Full Name

    CDC14 cell division cycle 14 homolog A (S. cerevisiae)

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.

  • Synonyms

    CDC14A;CDC14 cell division cycle 14 homolog A (S. cerevisiae);CDC10 (cell division cycle 10, S. cerevisiae, homolog);dual specificity protein phosphatase CDC14A;cdc14;Cdc14A1;Cdc14A2;CDC 10;Cdc 14;Cdc 14A;Cdc 14A1;Cdc 14A2;CDC10;CDC14 cell division cycle 14 homolog A;CDC14 homolog A;Cell Division Cycle 14 Homolog A;Dual specificity protein phosphatase CDC 14A;hCDC 14;hCDC14;OTTHUMP00000012653;OTTHUMP00000012654;OTTHUMP00000012655;OTTHUMP00000012656

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • Mammalian cells
  • His
  • GST
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
CDC14A-3828H Recombinant Human CDC14A protein, His-tagged E.coli Human His 1-191 aa
CDC14A-0898H Recombinant Human CDC14A Protein, GST-Tagged Wheat Germ Human GST
CDC14A-3126M Recombinant Mouse CDC14A Protein Mammalian Cell Mouse His
CDC14A-4089C Recombinant Chicken CDC14A Mammalian Cell Chicken His
CDC14A-1477M Recombinant Mouse CDC14A Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CDC14A-1477M-B Recombinant Mouse CDC14A Protein Pre-coupled Magnetic Beads HEK293 Mouse
CDC14A-3114HF Recombinant Full Length Human CDC14A Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 594 amino acids
Cdc14a-5762M Recombinant Mouse Cdc14a Protein (Met1-Tyr603), C-His tagged Mammalian cells Mouse His Met1-Tyr603
CDC14A-713H Recombinant Human CDC14A Protein, His&GST-tagged E.coli Human His&GST Met1-Lys199
Cdc14a-714M Recombinant Mouse Cdc14a Protein, His-tagged E.coli Mouse His Met1-Tyr212

    Involved Pathway

    CDC14A involved in several pathways and played different roles in them. We selected most pathways CDC14A participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC14A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle PCM1,SPO11,YWHAZ,TFDP1A,CSNK1E,CDKN1BB,PMF1,RAD50,AHCTF1,PSMC3IP

    Protein Function

    CDC14A has several biochemical functions, for example, hydrolase activity,phosphatase activity,phosphoprotein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC14A itself. We selected most functions CDC14A had, and list some proteins which have the same functions with CDC14A. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine phosphatase activity DUSP26,DUSP21,SSH2B,PTPREB,CDC14AA,PTENB,PTPRNA,RNGTT,DUSP19B,SSH2
    phosphoprotein phosphatase activity PPP3CCA,DUSP26,PTPN2B,PTPRZ1,PPEF2,SSH2,PPP1CC,SSH1,PPP1CAA,DUSP28
    phosphatase activity MINPP1B,PTPN2A,ACPL2,PTPRFB,ALP3,DUSP10,MTMR1A,EPHX2,PTP4A2B,DUSP19A
    protein tyrosine/serine/threonine phosphatase activity EYA3,DUSP10,DUSP12,PTPDC1,PTP4A3,DUSP23A,PTENB,DUSP21,PXYLP1,NT5DC3
    hydrolase activity KLK1B11,PPP3CCA,HE2,CTDSPL2A,ADPRM,LACTB,PARLA,CTS7,POR,ABHD14B
    protein serine/threonine phosphatase activity PPM1E,PPM1AB,CDC14AB,LCK,PPM1J,PP2D1,PPP6C,PPM1H,PPM1BA,PTEN

    Interacting Protein

    CDC14A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC14A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC14A.

    Resources

    Research Area

    Phosphatases and Regulators

    References

    • Marquis, M; Boulet, S; et al. The Non-Classical MAP Kinase ERK3 Controls T Cell Activation. PLOS ONE 9:-(2014).
    • Schindler, K; Schultz, RM; et al. The CDC14A phosphatase regulates oocyte maturation in mouse. CELL CYCLE 8:1090-1098(2009).

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