CCKBR
-
Official Full Name
cholecystokinin B receptor -
Overview
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008] -
Synonyms
CCKBR;cholecystokinin B receptor;GASR;CCK-B;CCK2R;gastrin/cholecystokinin type B receptor;CCK-BR;CCK2-R;CCK2 receptor;CCK-B receptor;gastrin receptor;cholecystokinin-2 receptor
Recombinant Proteins
- Chicken
- Rat
- Human
- Mouse
- Bovine
- Mus musculus
- Dog
- Oryctolagus cuniculus (Rabbit)
- Mastomys natalensis (African soft-furred rat) (Praomys natalensis)
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
- Fc
Involved Pathway
CCKBR involved in several pathways and played different roles in them. We selected most pathways CCKBR participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCKBR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | PRKCB,ATP1B4,CALML3,ATP1B3,KCNE2,ATP1A4,KCNK10,SLC9A1,GNAS,PRKACB |
| Neuroactive ligand-receptor interaction | TAAR10,PRL,CHRNA4B,PTGER3,GPR50,PTGER4B,C5AR1,HTR1D,C3AR1,CHRNA10 |
| Calcium signaling pathway | CAMK2B,CALM2A,PRKACB,ERBB3A,DRD5,PRKCBA,ATP2A1L,PTGER1B,TACR1,ADRB3B |
Protein Function
CCKBR has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity,cholecystokinin receptor activity,gastrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCKBR itself. We selected most functions CCKBR had, and list some proteins which have the same functions with CCKBR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholecystokinin receptor activity | CCKAR |
| protein binding | GTF3C4,PPAP2B,DYNLRB1,IGFBP2,ID4,SH3RF1,IRAK1BP1,XIRP2,AIDA,CPT1B |
| 1-phosphatidylinositol-3-kinase regulator activity | PIK3R3A,PIK3R1,PIK3R3,PIK3R3B,PIK3R2,PIK3R6,PIK3R5 |
| phosphatidylinositol phospholipase C activity | PLCL2,PLCB3,PLCD1,PLCH2,PLCH1,PLCB4,CCR1,PLCD4,PLCG2,C3AR1 |
Interacting Protein
CCKBR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCKBR here. Most of them are supplied by our site. Hope this information will be useful for your research of CCKBR.
PTPN11;NTM;ABL1;FYN;CCK;NCK1;GRB2;PPP1R9B;ATP13A2;Plcg1;Ptpn11
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