CBX5
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Official Full Name
chromobox homolog 5 -
Overview
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
CBX5;chromobox homolog 5;HP1;HP1A;HEL25;chromobox protein homolog 5;HP1-ALPHA;HP1Hs alpha;antigen p25;HP1 alpha homolog;epididymis luminal protein 25;heterochromatin protein 1-alpha;heterochromatin protein 1 homolog alpha;chromobox homolog 5 (HP1 alpha homolog, Drosophila)
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
- His&Myc
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CBX5 involved in several pathways and played different roles in them. We selected most pathways CBX5 participated on our site, such as Aurora B signaling,E2F transcription factor network,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Factors involved in megakaryocyte development and platelet production | MFN2,HBBE2,LRRC16A,DOCK7,ITPK1,ZFPM1,SH2B3,AKAP1,DOCK6,HBD |
| Hemostasis | HMG20B,GNA13B,SLC16A1,F13A1A.1,DOCK11,ESAMA,ANXA2B,HBB-Y,GRB7,NFE2 |
| E2F transcription factor network | HIC1,PRMT5,RBBP8,CEBPA,SMARCA2,UXT,E2F6,E2F4,MYBL2,CES1 |
| Aurora B signaling | CENPA,SGOL1,DES,EVI5,RACGAP1,NPM1,NDC80,AURKC,AURKB,PEBP1 |
Protein Function
CBX5 has several biochemical functions, for example, chromatin binding,histone deacetylase binding,methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX5 itself. We selected most functions CBX5 had, and list some proteins which have the same functions with CBX5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylated histone binding | ING3,RBBP5,PHF8,GLYR1,ING4,TP53BP1,RRP8,PHF19,CCDC101,L3MBTL1 |
| protein homodimerization activity | MTPAP,CSF1R,CR2,SLC9A7,SDCBP2,HARS2,ASCL1,BCL2L1,TDG,GDNF |
| repressing transcription factor binding | PARK7,TLE4,MAGEA2B,SRI,GMNN,PRDM5,HDAC7A,MAGEA2,EIF4E,TCF3 |
| protein binding, bridging | CAV1,NUFIP1,GOLGA5,DSP,SLC9A1,CNKSR1,MEN1,SPRR1A,ADAP2,PPP4R2 |
| protein binding | SH3RF1,CXCR5,ZBTB24,MTCH1,VASH1,MRC2,TGFBRAP1,CYB5R2,ATXN7L1,CEP104 |
| chromatin binding | RNF168,TRPS1,SMAD4,FOXN4,TOX3,MKRN1,AAAS,PAX3,PAF1,PELP1 |
| histone deacetylase binding | SFPQ,CEBPA,HDAC4,SIX3,NR2C1,TOP2B,MEF2B,HDAC10,CCND1,BCOR |
Interacting Protein
CBX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX5.
TRIM28;HIST1H3D;CHAF1A
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