CBFA2T2
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Official Full Name
core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -
Overview
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5-region of the RUNX1 (AML1) gene fused to the 3 -
Synonyms
CBFA2T2;core-binding factor, runt domain, alpha subunit 2;translocated to, 2;protein CBFA2T2;MTGR1;ZMYND3;MTG8-like protein;MTG8-related protein 1;ETO homolog on chromosome 20;ETO homologous on chromosome 20;myeloid translocation-related protein
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CBFA2T2-0451H | Recombinant Human CBFA2T2 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CBFA2T2-1881C | Recombinant Chicken CBFA2T2 | Mammalian Cell | Chicken | His |
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| CBFA2T2-2776M | Recombinant Mouse CBFA2T2 Protein | Mammalian Cell | Mouse | His |
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| CBFA2T2-7817HCL | Recombinant Human CBFA2T2 293 Cell Lysate | HEK293 | Human | Non |
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| CBFA2T2-1261M | Recombinant Mouse CBFA2T2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CBFA2T2-1261M-B | Recombinant Mouse CBFA2T2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CBFA2T2-2755HF | Recombinant Full Length Human CBFA2T2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 614 amino acids |
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| CBFA2T2-5030H | Recombinant Human CBFA2T2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Cbfa2t2-785M | Recombinant Mouse Cbfa2t2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
CBFA2T2 involved in several pathways and played different roles in them. We selected most pathways CBFA2T2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CBFA2T2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CBFA2T2 has several biochemical functions, for example, metal ion binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CBFA2T2 itself. We selected most functions CBFA2T2 had, and list some proteins which have the same functions with CBFA2T2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | NFKBIL2,RELB,RYBP,SP100,ARHGAP35,RUNX1T1,FOXP3,CBX4,NFIL3,CDX2 |
| protein binding | PARVA,HPX,RTN4,CTIF,USP36,TBXAS1,LAMTOR2,ILKAP,EIF4ENIF1,WBP2 |
| metal ion binding | TKTL2,PDE8A,ESRRGA,PKM,ADSSL,ALKBH7,COL1A1,BMPR1BA,EYA3,AMY2B |
| transcription factor activity, sequence-specific DNA binding | RUNX2B,PFDN1,RAB11FIP4A,HIVEP3,CBL,LEF1,ZNF174,SHOX,EOMESA,RUNX2A |
Interacting Protein
CBFA2T2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBFA2T2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBFA2T2.
MDFI;PRDM14;TCP1;PDP1;ZNF652;LBP;ATN1
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