CAV1
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Official Full Name
caveolin 1, caveolae protein, 22kDa -
Overview
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. -
Synonyms
CAV1;caveolin 1, caveolae protein, 22kDa;CAV, caveolin 1, caveolae protein, 22kD;caveolin-1;cell growth-inhibiting protein 32;CGL3;BSCL3;VIP21;MSTP085
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Chicken
- Dog
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- Yeast
- His
- Non
- His&GST
- GST
- His&Fc&Avi
- His&Myc
Involved Pathway
CAV1 involved in several pathways and played different roles in them. We selected most pathways CAV1 participated on our site, such as Endocytosis,Focal adhesion,Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ERBB3,SMAP2,TRAF6,PIP5K1A,RAB11FIP4A,WASH1,VPS26B,SMURF2,WASB,FAM21A |
| Focal adhesion | PAK7,ITGB4,VAV2,Reln,PXNA,MLCK2,ITGA1,ITGA4,FLT4,GSK3B |
| Proteoglycans in cancer | DROSHA,FZD7,HSPB2,HRAS,BRAF,WNT9A,PRKCB,PTPN6,FLNC,PPP1R12C |
| Viral myocarditis | H2-Q10,PRF1,ABL2,CXADR,RAC1,ACTG1,HLA-E,RAC3,CD80,HLA-DRB1 |
| Bacterial invasion of epithelial cells | RHOG,PIK3CD,ACTG1,VCL,GAB1,PTK2,SEPT12,CLTA,WAS,PXN |
Protein Function
CAV1 has several biochemical functions, for example, ATPase binding,MDM2/MDM4 family protein binding,RNA polymerase I transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAV1 itself. We selected most functions CAV1 had, and list some proteins which have the same functions with CAV1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | NDE1,ECI1,GOT1L1,ATF3,C1S,PTPRG,ATXN3,ORAI1,SLC2A1,USP4 |
| RNA polymerase I transcription factor binding | POLR1E |
| receptor binding | PVRL1B,FGF13B,CD160,FGF20A,FGF1A,Ren1,RIPK2,NPPA,MAP7,NMU |
| MDM2/MDM4 family protein binding | PSME3,CDK5RAP3,RFWD3,TRP53,CDKN2A,PPARA |
| protein kinase binding | CALM1,ITGB1BP1,HSP90AB1,SPDYE2,CCNB3,PTPN6,CD8A,NCS1,DNM2,BORA |
| protein complex scaffold | WWC1,AKAP9,PKP2,SLC9A1,MAGI3,WWC2,MAGI1B,ITSN1,CNOT1,MAP2K2 |
| nitric-oxide synthase binding | SLC14A2,CALM3,CDH2,DNM3,CAMK2D,ACTB,CAV3,CD74,SCN5A,CALM2 |
| structural molecule activity | COPB2,KRT24,KRTAP11-1,EVPLA,CLDN15LB,MAPK8IP2,SEMG2,ISCA2,CLDN2,CLDNF |
| cholesterol binding | APOA4A,APOA4,PMP2,APOA1A,OSBPL10,PTCH1,OSBPL5,OSBP2,ABCA1,TSPO |
Interacting Protein
CAV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAV1.
PTPN1;EGFR;TXNRD1;ID1
Resources
Research Area
Uptake and Transport Molecules on Endothelial CellsUptake and Transport Molecules in VSMC
Muscle Stem Cell Markers
Myogenesis Markers
Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
Focal Adhesion Adaptor and Scaffold Proteins
Myogenic Precursor Markers
Caveolin-mediated Endocytosis
Related Services
Related Products
References
- Biswas, SK; Brako, L; et al. Massive formation of square array junctions dramatically alters cell shape but does not cause lens opacity in the cav1-KO mice. EXPERIMENTAL EYE RESEARCH 125:9-19(2014).
