CASP14
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Official Full Name
caspase 14, apoptosis-related cysteine peptidase -
Overview
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.1 The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-14 has a conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis. -
Synonyms
CASP14;caspase 14, apoptosis-related cysteine peptidase;caspase 14, apoptosis related cysteine protease;caspase-14;apoptosis related cysteine protease;MGC119078;MGC119079;MICE;CASP-14;apoptosis-related cysteine protease;caspase 14, apoptosis-rel
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E. coli
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
CASP14 involved in several pathways and played different roles in them. We selected most pathways CASP14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CASP14 has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type endopeptidase activity involved in apoptotic signaling pathway,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP14 itself. We selected most functions CASP14 had, and list some proteins which have the same functions with CASP14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RCC2,MPHOSPH6,PSMB3,PODXL,TAC1,MED21,PIDD1,CNKSR3,DNAJC27,LGALSL |
| cysteine-type endopeptidase activity | Casp3,PDIA3,BLMH,CTSZ,USP48,USP15,MALT1A,ATG4B,CTSSB.1,USP28 |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | CFLAR,CASP10,CASP8,CFLARA,CASP9,CASP2,CASP8L1 |
Interacting Protein
CASP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP14.
MEOX2;PSAP;PRSS3;USP53;OTUB1;PRKAB1;CFTR;CD81
Resources
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References
- Ashokkumar, C; Sun, Q; et al. Antithymocyte Globulin Facilitates Alloreactive T-cell Apoptosis by Means of Caspase-3: Potential Implications for Monitoring Rejection-Free Outcomes. TRANSPLANTATION 99:164-170(2015).
- Younesi, V; Nejatollahi, F; et al. Induction of anti-proliferative and apoptotic effects by anti-IL-25 receptor single chain antibodies in breast cancer cells. INTERNATIONAL IMMUNOPHARMACOLOGY 23:624-632(2014).
