CAMKK2
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Official Full Name
calcium/calmodulin-dependent protein kinase kinase 2, beta -
Overview
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability toundergo autophosphorylation and to phosphorylate the downstream kinases. -
Synonyms
CAMKK2;calcium/calmodulin-dependent protein kinase kinase 2, beta;calcium/calmodulin-dependent protein kinase kinase 2;CAMKK;CAMKKB;KIAA0787;MGC15254;caM-KK 2;caM-KK beta;CAMKK beta protein;caM-kinase kinase 2;caM-kinase kinase beta;calcium/ca
Recombinant Proteins
- Human
- Rat
- Mouse
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- E.coli
- Insect (sf21)
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CAMKK2 involved in several pathways and played different roles in them. We selected most pathways CAMKK2 participated on our site, such as AMPK signaling,AMPK signaling pathway,Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMKK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | HIST1H3E,GNG3,SLC6A3,GNG4,HDAC2,H3F3A,HIST2H3C2,SHC1,BRAF,HIST1H2BP |
| AMPK signaling | PPARGC1B,CPT1A,ADRa1A,EEF2,EIF4EBP1,CPT1B,ADRA1B,CDKN1A,SLC2A4RG,ELAVL1 |
| Adipocytokine signaling pathway | STAT3,RXRGB,RELA,MAPK9,NPY,CAMKK1A,SOCS3B,SLC2A4,JAK2B,LEP |
| Oxytocin signaling pathway | CAMKK1,PPP3CA,PPP3R1,RHOA,GNAI2,MYLK4,RGS2,CALM3,PPP3CC,OXT |
| AMPK signaling pathway | PFKL,SLC2A4,PCK1,CAB39,GYS1,RPS6KB1,IRS1,MAP3K7,SCD5,PPP2R5D |
Protein Function
CAMKK2 has several biochemical functions, for example, ATP binding,calcium ion binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMKK2 itself. We selected most functions CAMKK2 had, and list some proteins which have the same functions with CAMKK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase activity | MAP2K7,KITB,TTK,SRC,DSTYK,PTK7A,NTRK3A,ERBB3B,MAP2K4,INSR |
| ATP binding | HSP90AB1,SLC27A2,HSPA5,ATP1A4,ULK1A,ACTR8,RUNX2B,ROCK1,MAPK7,PIK3R4 |
| calmodulin-dependent protein kinase activity | CAMK2A,CAMK1,DAPK1,MKNK2A,CAMK1GA,DCX,PNCK,ITPKA,MKNK2B,MAPKAPK2 |
| calcium ion binding | MICU2,RCN3,SLC24A4A,SYTL3,MATN3,CCDC48,SDF4,DGKAA,EFCAB9,PTBP3 |
| calmodulin binding | MYH13,PNCK,PHKG1A,ADD1,CNN2,SLC8A2,ITPKB,MYH3,TRPC2,RGS16 |
Interacting Protein
CAMKK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMKK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMKK2.
saicar;PKM;ESYT2;XPOT;OBSL1;HSP90AB1;FLNA;PRKAG1;PRKAA2;CALM1;PRKDC;IQGAP2;FLNC;SMC1A;MAPK14;GCN1L1;FANCI;SMC3;ATG4B
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