CACNA1C
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Official Full Name
Calcium Channel, Voltage-Dependent, L Type, Alpha 1C Subunit -
Overview
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Specifically, Cav1.2 is a cardiac L-type calcium channel and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothy’s syndrome and also with Brugada syndrome. Some references suggest it is related to bipolar disease as well. -
Synonyms
CACNA1C;Cav1.2 Calcium Channel;calcium channel, voltage-dependent, L type, alpha 1C subunit;TS;CACH2;CACN2;CaV1.2;CCHL1A1;CACNL1A1;MGC120730;voltage-dependent L-type calcium channel subunit alpha-1C;DHPR, alpha-1 subunit;calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit;calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle;voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*;Voltage-gated calcium channel subunit alpha Cav1.2;OTTHUMP00000196730;OTTHUMP00000196731;OTTHUMP00000196732;OTTHUMP00000196733;OTTHUMP00000196734;OTTHUMP00000196735;OTTHUMP00000196736;OTTHUMP00000196737;OTTHUMP00000196738;OTTHUMP00000196739;OTTHUMP00000196740;OTTHUMP00000196741;OTTHUMP00000196742;OTTHUMP00000196743;OTTHUMP00000196744;OTTHUMP00000196745;OTTHUMP00000196746;OTTHUMP00000196747;OTTHUMP00000196748;OTTHUMP00000196749;OTTHUMP00000196750;OTTHUMP00000196751;OTTHUMP00000238277;OTTHUMP00000238278;OTTHUMP00000238279
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Guinea pig
- Chicken
- Wheat Germ
- E.coli
- Mammalian Cells
- GST
- His
- T7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CACNA1C-0264H | Recombinant Human CACNA1C Protein, GST-Tagged | Wheat Germ | Human | GST |
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| Cacna1c-1423M | Recombinant Mouse Cacna1c protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ser1978~Leu2139 |
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| CACNA1C-9399Z | Recombinant Zebrafish CACNA1C | Mammalian Cells | Zebrafish | His |
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| CACNA1C-01G | Recombinant Guinea pig CACNA1C Full Length Transmembrane protein, His-tagged | E.coli | Guinea pig | His | Full L. 1-169aa |
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| CACNA1C-117H | Recombinant Human CACNA1C protein, His-tagged | E.coli | Human | His | Glu431-Asn510 |
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| RFL11969GF | Recombinant Full Length Chicken Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C(Cacna1C) Protein, His-Tagged | E.coli | Chicken | His | Full L. Full Length (1-177) |
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| RFL29137CF | Recombinant Full Length Guinea Pig Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C(Cacna1C) Protein, His-Tagged | E.coli | Guinea pig | His | Full L. Full Length (1-169aa) |
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Involved Pathway
CACNA1C involved in several pathways and played different roles in them. We selected most pathways CACNA1C participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GnRH signaling pathway | MAP2K4A,CAMK2A,CALM,MAP2K4B,MMP14A,ITPR3,RAF1,PRKACG,GNRH2,GNAS |
| Adrenergic signaling in cardiomyocytes | PPP1CA,PRKACA,BCL2A,NETO2,AGTR2,PIK3R2,TNNC1,GNAS,CACNA1D,MYL3 |
| Calcium signaling pathway | ADRB2B,CAMK4,HTR2C,ADRB3B,PRKACBB,ORAI1B,HTR7,PHKG1A,CAMK2A,EDNRB |
| MAPK signaling pathway | IL1B,STK3,MAP2K2A,CACNG8,FASLG,MEF2CB,MAPKAPK2,ELK1,ACVR1C,MEF2C |
| Cardiac muscle contraction | CACNG8,SLC9A1,ATP1B3,MYL3,TNNC1B,CACNB4A,COX7B2,CACNB1,CACNG2,CACNA2D1 |
| Vascular smooth muscle contraction | PRKCQ,PRKCD,PPP1R14AB,PRKCBA,ADORA2AB,BRAF,MAP2K1,RHOAC,MYL9A,PPP1CAA |
Protein Function
CACNA1C has several biochemical functions, for example, calcium channel activity,high voltage-gated calcium channel activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1C itself. We selected most functions CACNA1C had, and list some proteins which have the same functions with CACNA1C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated calcium channel activity | GRM7,PKD2,TPCN2,NALCN,GAS6,CACNA1DA,CACNA1SB,CACNA2D4,CACNB2A,CACNG2B |
| high voltage-gated calcium channel activity | CACNB4B,CACNB2A,CACNA1B,CACNB3,CACNB1,CACNB3A,CACNB4A,CACNA1SA,CACNA1BA,CACNB2B |
| calcium channel activity | PDE2A,SLC24A4,TRPC4A,UBXN6,TRPM1,TRPM2,TRPM8,CACNA1DA,GRIN3A,CACNA1SA |
| voltage-gated ion channel activity | CLIC5A,CLIC5,SCN8AA,SCN12AA,CACNG8A,CLCN3,CLIC3,CACNA1DA,KCNJ1A.5,KCNJ1B |
| ion channel activity | GRIN1A,CLCN4-2,FXYD6,GJC1,GRIN1B,ASIC4,KCNC1B,TRPA1B,TRPN1,CHRNB1L |
Interacting Protein
CACNA1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1C here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1C.
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References
- Wenzel, K; Haase, H; et al. Potential Relevance of alpha(1)-Adrenergic Receptor Autoantibodies in Refractory Hypertension. PLOS ONE 3:-(2008).
