BTG1
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Official Full Name
B-cell translocation gene 1, anti-proliferative -
Overview
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. -
Synonyms
BTG1;B-cell translocation gene 1, anti-proliferative;protein BTG1;B-cell translocation gene 1 protein
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- HIS
- Non
- His&Fc&Avi
Involved Pathway
BTG1 involved in several pathways and played different roles in them. We selected most pathways BTG1 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with BTG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | PAN2,ENO1,C1D,TOB2,ZCCHC7,CNOT3B,CNOT3A,EXOSC10,ENO3,CNOT10 |
Protein Function
BTG1 has several biochemical functions, for example, enzyme binding,kinase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BTG1 itself. We selected most functions BTG1 had, and list some proteins which have the same functions with BTG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase binding | JAKMIP2,WWC2,MOB4,ABI2,NTRK1,CEBPB,HSP90AB1,MOBKL1A,DGKQ,PRKCD |
| transcription cofactor activity | ZMYND11,LDB2,MED16,ZNF865,MSX2,MED1,LDB2B,TRIP13,KAT2B,FAM48A |
| protein binding | PFKM,E2F6,CRYAB,ARHGEF10,VPS18,HNRNPA1,SEPSECS,PDLIM5,FYTTD1,NDRG1 |
| enzyme binding | YWHAE,UGT1A6,CTNNB1,DAOA,CREB1,ZNHIT6,ARRB2,MSH3,HSPA6,RYR2 |
Interacting Protein
BTG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BTG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BTG1.
CNOT8;CNOT7;Cnot7;XRCC6;TUBA1A;RNF181
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