BPNT1
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Official Full Name
3(2), 5-bisphosphate nucleotidase 1 -
Overview
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntases physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. -
Synonyms
BPNT1;3(2), 5-bisphosphate nucleotidase 1;3(2),5-bisphosphate nucleotidase 1;BPntase;PAP-inositol-1,4-phosphatase;bisphosphate 3-nucleotidase 1;PIP
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
BPNT1 involved in several pathways and played different roles in them. We selected most pathways BPNT1 participated on our site, such as Biological oxidations,Biosynthesis of antibiotics,Cytosolic sulfonation of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with BPNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sulfur metabolism | SUOX,cysH,PAPSS2,TST,PAPSS2A,SQRDL,CYCS,PAPSS1,CYCSB,MPST |
| Cytosolic sulfonation of small molecules | SULT1C2,SULT2ST1,SULT4A1,SLC26A1,SULT1B1,SLC26A2,SLC35B3,ABHD14B,SULT1ST5,Sult2a2 |
| Phase II conjugation | SULT1C2,UGT1B4,GGTLC1,UGT1B5,SULT1ST5,GLYATL2,TPMT.2,SLC35B3,SLC35B2,SULT2ST1 |
| Biological oxidations | CYP4A11,CYP2W1,SLC35D1A,DPEP1,Sult2a2,CYP2C18,CYP3A5,CYP2AD6,CYP2K6,SULT2ST1 |
| Metabolism | CPOX,MED19,ANKRD1,CA13,SULT2ST2,LMF1,UGT1B3,LBR,CYP17A1,NUDT3 |
| Metabolic pathways | P4HA1A,TDO2A,ATP6V0B,POLR1E,UGT1A3,ALPL,NT5M,DHRS4L2,PAPSS2,ACADS |
| Biosynthesis of antibiotics | DBT,AKR1A1,LDHAL6A,GPR19,SDSL,DAO1,ADSL,EHHADH,AK7,AMDHD2 |
Protein Function
BPNT1 has several biochemical functions, for example, 3(2),5-bisphosphate nucleotidase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BPNT1 itself. We selected most functions BPNT1 had, and list some proteins which have the same functions with BPNT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | STK3,RPS6KA6,PGP,FOXK2,DOM3Z,PI4K2A,FIGNL1,ENOSF1,STK38L,CDC42BPG |
| 3(2),5-bisphosphate nucleotidase activity | IMPAD1 |
Interacting Protein
BPNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BPNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BPNT1.
IKBKE;TRAF6;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;IQCB1
Resources
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References
- Tarique, KF; Rehman, SAA; et al. Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:3023-3033(2014).
- Tarique, KF; Rehman, SAA; et al. Structural elucidation of a dual-activity PAP phosphatase-1 from Entamoeba histolytica capable of hydrolysing both 3 '-phosphoadenosine 5 '-phosphate and inositol 1,4-bisphosphate. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:2019-2031(2014).
