BPGM
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Official Full Name
2,3-bisphosphoglycerate mutase -
Overview
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
BPGM;2,3-bisphosphoglycerate mutase;bisphosphoglycerate mutase;BPG-dependent PGAM;2,3-diphosphoglycerate mutase;2,3-bisphosphoglycerate synthase;erythrocyte 2,3-bisphosphoglycerate mutase;2,3-bisphosphoglycerate mutase, erythrocyte;DPGM
Recombinant Proteins
- Human
- Mouse
- Chicken
- Cynomolgus
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- E. coli
- Mammalian cells
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
BPGM involved in several pathways and played different roles in them. We selected most pathways BPGM participated on our site, such as Glycolysis / Gluconeogenesis,Glycine, serine and threonine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with BPGM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | LDHB,GAPDH,LDHBA,PCK2,AKR1A1B,ALDOB,GPIB,ALDH9A1,PDHA1A,PDHB |
| Metabolic pathways | DGKD,ACSM2,PKM,NDUFS1,PDHA1,POLR2A,ALG10,SC4MOL,ARG1,GPAA1 |
| Glycine, serine and threonine metabolism | CBSA,DLDH,GRHPRA,DAO.1,GCSH,DAO1,ALAS2,GRHPRB,GCSHA,ALDH7A1 |
Protein Function
BPGM has several biochemical functions, for example, bisphosphoglycerate 2-phosphatase activity,bisphosphoglycerate mutase activity,catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BPGM itself. We selected most functions BPGM had, and list some proteins which have the same functions with BPGM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| catalytic activity | GOT2B,PPM1LA,CTHL,HSD17B1,LGI3,ECI2,SYN2A,LANCL1,CAPN3,Amy1 |
| hydrolase activity | LIPN,GDPD4,DDX51,RNASEKB,Ces2c,LACTB,PA2G4B,FAHD2B,CTSSB.1,CAPN1B |
| intramolecular transferase activity, phosphotransferases | PGAM1A,PGAM1B,PGAM1 |
| bisphosphoglycerate 2-phosphatase activity | TIGARA,PGAM2,TIGARB,PGAM1,C12orf5 |
| isomerase activity | PDIA5,PPIAB,PDIP5,TSTA3,FKBP1AA,ITPK1A,GPIA,PBLD2,PGAM1,GSBP9 |
| molecular_function | SERHL,DHRS7B,MCART1,TTC36,FRAT2,SCAND2P,GM7903,ZNF664,CCDC85AL,DYTN |
| bisphosphoglycerate mutase activity | PGAM2,PGAM1 |
| phosphoglycerate mutase activity | PGAM1B,PGAM2,PGAM1,PGAM1A |
Interacting Protein
BPGM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BPGM here. Most of them are supplied by our site. Hope this information will be useful for your research of BPGM.
Ywhae
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